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Aging of Epidermal Stem Cells

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Textbook of Aging Skin

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Abstract

Advances in aging biology indicate that stem cells have a crucial role in organ maturation and aging. Studies have demonstrated molecular and biochemical changes in tissue-resident progenitor cells and their microenvironments during chronological aging of tissues such as the heart [1], brain [2], and hematopoietic system [3]. In this chapter knowledge in the field of aging and stem cells derived from tissues other than the epidermis is reviewed, and the challenges of studying aging stem cells discussed. Subsequently, epidermal stem cells are reviewed and changes in progenitor populations of the epidermis that occur with age discussed. Finally, the body of knowledge specifically related to the aging of epidermal stem cells and the implications of stem cell aging for carcinogenesis are examined.

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Author information

Authors and Affiliations

  1. Dept. of Dermatology and Institute for Regeneration Medicine, University of California, San Francisco,  

    Alexandra Charruyer & Ruby Ghadially

  2. Veterans Affairs Medical Center, San Francisco,  

    Alexandra Charruyer & Ruby Ghadially

Authors
  1. Alexandra Charruyer
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  2. Ruby Ghadially
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Corresponding author

Correspondence to Ruby Ghadially .

Editor information

Editors and Affiliations

  1. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Miranda A. Farage Ph.D. (Principal Scientist) (Principal Scientist)

  2. The Procter & Gamble Company, 6110 Center Hill Avenue, 45224, Cincinnati, OH, USA

    Kenneth W. Miller Ph.D. (Associate Director) (Associate Director)

  3. Department of Dermatology, University of California, School of Medicine, 222 SE 8th Ave., Suite 563, 94122, San Francisco, CA, USA

    Howard I. Maibach M.D. (Professor) (Professor)

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Charruyer, A., Ghadially, R. (2010). Aging of Epidermal Stem Cells. In: Farage, M.A., Miller, K.W., Maibach, H.I. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89656-2_19

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  • DOI: https://doi.org/10.1007/978-3-540-89656-2_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-89655-5

  • Online ISBN: 978-3-540-89656-2

  • eBook Packages: MedicineReference Module Medicine

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