Definition
ABC transporters are a superfamily of prokaryotic and eukaryotic proteins. They are usually involved in membrane transport and share a homologous nucleotide-binding domain, ABC (ATP-binding cassette). In addition to the ABC domain, ABC transporters contain or interact with hydrophobic domains containing multiple transmembrane segments. Examples of mammalian ABC transporters include P-glycoprotein, MRP (multidrug-resistance protein), cystic fibrosis transmembrane conductance regulator (CFTR) and the transporter associated with antigen processing (TAP).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg New York
About this entry
Cite this entry
(2008). ABC Transporter. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_11
Download citation
DOI: https://doi.org/10.1007/978-3-540-47648-1_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-36847-2
Online ISBN: 978-3-540-47648-1
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences