N‐Acetyltransferases (NATs) catalyze the conjugation of an acetyl group from acetyl‐CoA on to an amine, hydrazine or hydroxylamine moiety of an aromatic compound. NATs are involved in a variety of phase II‐drug metabolizing processes. There are two isozymes NAT I and NAT II, which possess different substrate specificity profiles. The genes encoding NAT I and NAT II are both multi‐allelic. Especially for NAT II, genetic polymorphisms have been shown to result in different phenotypes (e.g., fast and slow acetylators).
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© 2008 Springer-Verlag Berlin Heidelberg New York
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(2008). N‐Acetyltransferases. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38918-7_5016
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DOI: https://doi.org/10.1007/978-3-540-38918-7_5016
Publisher Name: Springer, Berlin, Heidelberg
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