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Delusion and Dopamine: Neuronal Insights in Psychotropic Drug Therapy

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NeuroPsychopharmacotherapy

Abstract

Delusions are a central topic for neuropsychiatric research given their insidious psychotic nature. According to the Bayesian brain hypothesis (predictive coding theory), delusions are regarded as an aberrant inference process. It is believed that an excess of dopamine contributes to abnormal salience attribution, which is considered to be the basis of delusional formation. This is explained in detail by the neuromodulatory effect of dopamine on the integration of prediction errors and aberrant prediction errors respectively, into a person’s thinking. All currently approved antipsychotics block dopamine receptors, usually by D2 dopamine receptor antagonism. Available clinical data points toward a good response to antipsychotic therapy in delusional disorders. A timely and adequate antipsychotic treatment of patients with delusions, accompanied by a stable and trusting doctor-patient relationship, is recommended.

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Authors and Affiliations

  1. Department of Psychiatry, General Hospital Bruneck, South Tyrol, Italy

    Markus Karl Huber & Erwin Kirchler

  2. Department of Psychiatry, General Hospital Brixen, South Tyrol, Italy

    Josef Schwitzer

  3. Wrexham Academic Unit, Bangor University, Bangor, Wales, UK

    Peter Lepping

  4. Heddfan Psychiatric Unit, Betsi Cadwaladr University Health Board, Wrexham, Wales, UK

    Peter Lepping

  5. Mysore Medical College/Research Institute, Honorary Professor Bangor University, Mysore, India

    Peter Lepping

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  1. Markus Karl Huber
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  2. Josef Schwitzer
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  4. Peter Lepping
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Correspondence to Markus Karl Huber .

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  1. Dept Psychiatry , Psychosomatics & Psychotherapy, University of WĂĽrzburg, Medical School Clinical Neurochemistry, WĂĽrzburg, Germany

    Peter Riederer

  2. Inst fĂĽr Psychologische Medizin, Haag, Bayern, Germany

    Gerd Laux

  3. Fujita Health University School Medicine, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

  4. Center Translational Res Neurol Diseases, Dalian Med Uni Shanghai Inst Health Sc Center Translational Res Neurol Diseases, Dalian, China

    Weidong Le

  5. WĂĽrzburg, Bayern, Germany

    Christian Riederer

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  1. Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital WĂĽrzburg, WĂĽrzburg, Germany

    Peter Riederer

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Huber, M.K., Schwitzer, J., Kirchler, E., Lepping, P. (2021). Delusion and Dopamine: Neuronal Insights in Psychotropic Drug Therapy. In: Riederer, P., Laux, G., Nagatsu, T., Le, W., Riederer, C. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-56015-1_411-1

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