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Trials in Older Adults

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Principles and Practice of Clinical Trials

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Abstract

This chapter discusses several unique features of clinical trials in older adults such as ethics in geriatric medicine research; recruitment and retention, including barriers to participation by older adults in clinical trials; selection of outcomes that are important to this population; effects of polypharmacy and multimorbidity on trial design; time to benefit, time to harm and life expectancy; and multimodal interventions targeting numerous risk factors and/or pathways for diseases and conditions associated with aging. This chapter also discusses unique features of trials in patients with Alzheimer’s Disease (AD) and AD-related dementias (ADRD).

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Authors and Affiliations

  1. National Institutes of Health, National Institute on Aging, Bethesda, MD, USA

    Sergei Romashkan & Laurie Ryan

Authors
  1. Sergei Romashkan
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  2. Laurie Ryan
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Corresponding author

Correspondence to Sergei Romashkan .

Editor information

Editors and Affiliations

  1. Samuel Oschin Comprehensive Cancer Insti, WEST HOLLYWOOD, CA, USA

    Steven Piantadosi

  2. Bloomberg School of Public Health, Johns Hopkins Center for Clinical Trials Bloomberg School of Public Health, Baltimore, MD, USA

    Curtis L. Meinert

Section Editor information

  1. Rockville, Maryland, USA

    Lawrence Friedman

  2. Director, Office of Biostatistics Research, National Heart Lung and Blood Institute (NHLBI), Bethesda, MD, USA

    Nancy L Geller

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© 2020 This is a U.S. Government work and not under copyright protection in the U.S.; foreign copyright protection may apply

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Romashkan, S., Ryan, L. (2020). Trials in Older Adults. In: Piantadosi, S., Meinert, C. (eds) Principles and Practice of Clinical Trials. Springer, Cham. https://doi.org/10.1007/978-3-319-52677-5_260-1

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  • DOI: https://doi.org/10.1007/978-3-319-52677-5_260-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-52677-5

  • Online ISBN: 978-3-319-52677-5

  • eBook Packages: Springer Reference MathematicsReference Module Computer Science and Engineering

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