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Blue Nevus

  • Reference work entry
  • First Online:
Dermatopathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 1527 Accesses

Synonyms

Blue nevus; Jadassohn-Tieche nevus; Jadassohn-Tieche nevus

Definition

Blue nevi are benign acquired melanocytic lesions characterized by the presence of distinctive pigmented dermal dendritic melanocytes. The morphological spectrum includes common blue nevi and its most significant variants cellular blue nevus, plaque-type blue nevus, and epithelioid blue nevus.

Clinical Features

  • Incidence

    No precise data regarding incidence are available but “common” blue nevi are not infrequently encountered. The variants of blue nevus as described below are significantly less common. Epithelioid blue nevi may arise sporadic or in association with Carney complex.

  • Age

    Blue nevi can present at any age including at birth. Adolescents and young adults are predominantly affected.

  • Sex

    There is an approximately twofold female predilection.

  • Site

    Blue nevi affect a wide spectrum of anatomical sites. Common blue nevusshows a predilection for the dorsum of the hands and feet as well as the face and...

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References and Further Reading

  • Busam, K. J. (1999). Metastatic melanoma to the skin simulating blue naevus. The American Journal of Surgical Pathology, 23(3), 276–282.

    Article  CAS  PubMed  Google Scholar 

  • Busam, K. J., Woodruff, J. M., Erlandson, R. A., & Brady, M. S. (2000). Large plaque-type blue naevus with subcutaneous cellular nodules. The American Journal of Surgical Pathology, 24(1), 92–99.

    Article  CAS  PubMed  Google Scholar 

  • Granter, S. R., McKee, P. H., Calonje, E., Mihm, M. C., Jr., & Busam, K. (2001). Melanoma associated with blue naevus and melanoma mimicking cellular blue naevus: A clinicopathologic study of 10 cases on the spectrum of so-called ‘malignant blue naevus’. The American Journal of Surgical Pathology, 25(3), 316–323.

    Article  CAS  PubMed  Google Scholar 

  • Van Raamsdonk, C. D., Bezrookove, V., Green, G., Bauer, J., Gaugler, L., O’Brien, J. M., Simpson, E. M., Barsh, G. S., & Bastian, B. C. (2009). Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature, 457(7229), 599–602.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zembowicz, A., Granter, S. R., McKee, P. H., & Mihm, M. C. (2002). Amelanotic cellular blue naevus: A hypopigmented variant of the cellular blue naevus: Clinicopathologic analysis of 20 cases. The American Journal of Surgical Pathology, 26(11), 1493–1500.

    Article  PubMed  Google Scholar 

  • Zembowicz, A., Knoepp, S. M., Bei, T., Stergiopoulos, S., Eng, C., Mihm, M. C., & Stratakis, C. A. (2007). Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions. The American Journal of Surgical Pathology, 31(11), 1764–1775.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Western General Hospital, The University of Edinburgh, Alexander Donald Building, 1st Floor, Crewe Road, Edinburgh, EH4 2XU, UK

    Thomas Brenn

Authors
  1. Thomas Brenn
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Corresponding author

Correspondence to Thomas Brenn .

Editor information

Editors and Affiliations

  1. Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, School of Human Health Sciences, Florence, Italy

    Daniela Massi

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© 2016 Springer International Publishing Switzerland

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Cite this entry

Brenn, T. (2016). Blue Nevus. In: Massi, D. (eds) Dermatopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-30006-1_452

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  • DOI: https://doi.org/10.1007/978-3-319-30006-1_452

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-30005-4

  • Online ISBN: 978-3-319-30006-1

  • eBook Packages: MedicineReference Module Medicine

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