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Genetics of Lipid Disorders

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Metabolic Syndrome

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Abstract

This chapter focuses on the genetics of common lipid disorders, collectively referred to as “dyslipidemia,” a component of the metabolic syndrome (MetSyn). We begin by providing a brief background on the lipids discussed in this chapter. Then, we discuss specific variants in key candidate genes and their role in related pathways that have been associated with individual lipid levels and dyslipidemia in larger-scale studies. In addition, we comment on associations observed in genome-wide association studies (GWAS) and sequencing studies. We also discuss how the use of more sophisticated statistical methods (e.g., genetic risk scores and pathway modeling) are helping to better understand the collective effects of multiple variants in multiple genes on these lipid traits. We conclude by providing perspectives for future directions.

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  1. Department of Epidemiology and Biostatistics, Case Western University School of Medicine, Cleveland, OH, USA

    Nora L. Nock

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  1. Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Rexford S. Ahima

  2. Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA, USA

    Rexford S. Ahima

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Nock, N.L. (2016). Genetics of Lipid Disorders. In: Ahima, R.S. (eds) Metabolic Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-11251-0_12

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