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ACKR3

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Encyclopedia of Inflammatory Diseases

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Synonyms

Atypical chemokine receptor 3, for the ligands CXCL12, CXCL11, and adrenomedullin; CMKOR; CXCR7; GPR159; RDC1

Definition

ACKR7 is a seven-transmembrane domain receptor phylogenetically related to the rhodopsin-like family of G protein-coupled receptors (GPCRs) which binds the chemokines CXCL12/SDF-1 (Kd ~ 0.4 nM) and CXCL11/I-TAC (Kd ~ 4 nM) and the peptide hormone adrenomedullin (Kd ~ 0.2 nM), but appears not to couple to heterotrimeric G proteins. Therefore, ACKR3 should not be classified as GPCR rather as a seven-transmembrane domain receptor (7TMDR) (Balabanian et al. 2005; Burns et al. 2006; Kapas and Clark 1995; Klein et al. 2014). Nevertheless, ACKR3 is a functional cell surface receptor as it shows ligand-induced responses such as enhanced internalization and arrestin recruitment. Because ACKR3 does not induce typical chemokine receptor responses in cells, such as chemotaxis, the receptor belongs to the group of atypical chemokine receptors (Bachelerie et al. 2014b)....

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Authors and Affiliations

  1. Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH-6500, Bellinzona, Switzerland

    Marcus Thelen

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  1. Marcus Thelen
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Correspondence to Marcus Thelen .

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Editors and Affiliations

  1. Inst of Clinical Pharmacology Haus 74/75, JW Goethe University Frankfurt Fraunhofer IME, Frankfurt, Germany

    Michael Parnham

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Thelen, M. (2015). ACKR3. In: Parnham, M. (eds) Encyclopedia of Inflammatory Diseases. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-0620-6_222-1

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  • DOI: https://doi.org/10.1007/978-3-0348-0620-6_222-1

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  • Publisher Name: Birkhäuser, Basel

  • Online ISBN: 978-3-0348-0620-6

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