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Autophagy and Inflammation

  • Living reference work entry
  • First Online:
Encyclopedia of Inflammatory Diseases

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Synonyms

Autophagosome-mediated pathway; Autophagy pathway; Evolutionarily conserved degradative and recycling process; Lysosome-mediated long-lived cytoplasmic component degradative pathway; Macroautophagy

Definition

Macroautophagy (referred to hereafter simply as autophagy) is an evolutionarily conserved homeostatic mechanism involving the formation of autophagosomes that sequester cytoplasmic macromolecules and organelles before fusing with the endo-/lysosomal compartment. Accumulating evidence indicates that the autophagy pathway influences the inflammation process at several different levels. More importantly, deficiencies of the autophagy pathway or autophagy proteins are reportedly involved in several inflammatory disorders – underscoring the key role of autophagy in inflammation responses. The recent findings provide evidence that the autophagy pathway and autophagy proteins may constitute an intrinsic cellular platform that ensures the beneficial effects of the host immune...

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Authors and Affiliations

  1. INSERM U984, Paris-Sud 11 University, 92296, Châtenay-Malabry, France

    Ahmed Hamaï, Joëlle Botti & Patrice Codogno

  2. Medical School, Paris 7 University, Denis Diderot, 75010, Paris, France

    Joëlle Botti

Authors
  1. Ahmed Hamaï
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  2. Joëlle Botti
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  3. Patrice Codogno
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Corresponding author

Correspondence to Patrice Codogno .

Editor information

Editors and Affiliations

  1. Inst of Clinical Pharmacology Haus 74/75, JW Goethe University Frankfurt Fraunhofer IME, Frankfurt, Germany

    Michael Parnham

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Hamaï, A., Botti, J., Codogno, P. (2013). Autophagy and Inflammation. In: Parnham, M. (eds) Encyclopedia of Inflammatory Diseases. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-0620-6_183-2

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  • DOI: https://doi.org/10.1007/978-3-0348-0620-6_183-2

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  • Publisher Name: Birkhäuser, Basel

  • Online ISBN: 978-3-0348-0620-6

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