Skip to main content

Abstract

Colorectal cancer is one of the most frequent cancers worldwide and represents the most common cause of colon obstruction. Historically, the treatment of acute neoplastic obstruction is represented by a surgical resection in an emergency context, an approach with a high risk of postoperative complications and mortality. Recently, the use of a colonic stent, endoscopically released to overcome obstruction, has been proposed. The purpose of colon stenting is to transform a case that has required emergency surgery into an elective surgical case. It aims to reduce morbidity, mortality, and stoma creation. However, concern was raised about the long-term survival and cancer safety of this new approach, so the European Society for Gastrointestinal Endoscopy initially did not recommend the stent as a bridge to surgery as a standard treatment in left colon obstruction. But recent scientific evidence has shown that this approach is effective and safe as it reduces postoperative complications, the stoma rate without differences in cancer outcomes compared to emergency surgery. Therefore, the European Society for Gastrointestinal Endoscopy in their latest update has reconsidered stenting as a bridge to surgery as a valid alternative to emergency surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Similar content being viewed by others

References

  1. Alcantara M, Serra-Aracil X, Falco J, Mora L, Bombardo J, Navarro S (2011) Prospective, controlled, randomized study of intraoperative colonic lavage versus stent placement in obstructive left-sided colonic cancer. World J Surg 35(8):1904–1910. https://doi.org/10.1007/s00268-011-1139-y

    Article  CAS  PubMed  Google Scholar 

  2. Allievi N, Ceresoli M, Fugazzola P, Montori G, Coccolini F, Ansaloni L (2017) Endoscopic stenting as bridge to surgery versus emergency resection for left-sided malignant colorectal obstruction: an updated meta-analysis. Int J Surg Oncol 2017:2863272. https://doi.org/10.1155/2017/2863272

    Article  PubMed  PubMed Central  Google Scholar 

  3. Amelung FJ, de Beaufort HW, Siersema PD, Verheijen PM, Consten EC (2015) Emergency resection versus bridge to surgery with stenting in patients with acute right-sided colonic obstruction: a systematic review focusing on mortality and morbidity rates. Int J Color Dis 30(9):1147–1155. https://doi.org/10.1007/s00384-015-2216-8

    Article  CAS  Google Scholar 

  4. Amelung FJ, Consten ECJ, Siersema PD, Tanis PJ (2016a) A population-based analysis of three treatment modalities for malignant obstruction of the proximal colon: acute resection versus stent or stoma as a bridge to surgery. Ann Surg Oncol 23(11):3660–3668. https://doi.org/10.1245/s10434-016-5247-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Amelung FJ, Ter Borg F, Consten EC, Siersema PD, Draaisma WA (2016b) Deviating colostomy construction versus stent placement as bridge to surgery for malignant left-sided colonic obstruction. Surg Endosc 30(12):5345–5355. https://doi.org/10.1007/s00464-016-4887-9

    Article  PubMed  Google Scholar 

  6. Amelung FJ, Draaisma WA, Consten ECJ, Siersema PD, Ter Borg F (2017) Self-expandable metal stent placement versus emergency resection for malignant proximal colon obstructions. Surg Endosc 31(11):4532–4541. https://doi.org/10.1007/s00464-017-5512-2

    Article  PubMed  Google Scholar 

  7. Amelung FJ, Burghgraef TA, Tanis PJ, van Hooft JE, Ter Borg F, Siersema PD, Bemelman WA, Consten ECJ (2018) Critical appraisal of oncological safety of stent as bridge to surgery in left-sided obstructing colon cancer; a systematic review and meta-analysis. Crit Rev Oncol Hematol 131:66–75. https://doi.org/10.1016/j.critrevonc.2018.08.003

    Article  PubMed  Google Scholar 

  8. Arezzo A, Balague C, Targarona E, Borghi F, Giraudo G, Ghezzo L, Arroyo A, Sola-Vera J, De Paolis P, Bossotti M, Bannone E, Forcignano E, Bonino MA, Passera R, Morino M (2017a) Colonic stenting as a bridge to surgery versus emergency surgery for malignant colonic obstruction: results of a multicentre randomised controlled trial (ESCO trial). Surg Endosc 31(8):3297–3305. https://doi.org/10.1007/s00464-016-5362-3

    Article  PubMed  Google Scholar 

  9. Arezzo A, Passera R, Lo Secco G, Verra M, Bonino MA, Targarona E, Morino M (2017b) Stent as bridge to surgery for left-sided malignant colonic obstruction reduces adverse events and stoma rate compared with emergency surgery: results of a systematic review and meta-analysis of randomized controlled trials. Gastrointest Endosc 86(3):416–426. https://doi.org/10.1016/j.gie.2017.03.1542

    Article  PubMed  Google Scholar 

  10. Baer C, Menon R, Bastawrous S, Bastawrous A (2017) Emergency presentations of colorectal cancer. Surg Clin North Am 97(3):529–545. https://doi.org/10.1016/j.suc.2017.01.004

    Article  PubMed  Google Scholar 

  11. Baron TH, Wong Kee Song LM, Repici A (2012) Role of self-expandable stents for patients with colon cancer (with videos). Gastrointest Endosc 75(3):653–662. https://doi.org/10.1016/j.gie.2011.12.020

    Article  PubMed  Google Scholar 

  12. Benson AB, Venook AP, Al-Hawary MM, Cederquist L, Chen YJ, Ciombor KK, Cohen S, Cooper HS, Deming D, Engstrom PF, Garrido-Laguna I, Grem JL, Grothey A, Hochster HS, Hoffe S, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Murphy JD, Nurkin S, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Wuthrick E, Gregory KM, Freedman-Cass DA (2018) NCCN guidelines insights: colon cancer, version 2.2018. J Natl Compr Cancer Netw 16(4):359–369. https://doi.org/10.6004/jnccn.2018.0021

    Article  Google Scholar 

  13. Cheynel N, Cortet M, Lepage C, Benoit L, Faivre J, Bouvier AM (2007) Trends in frequency and management of obstructing colorectal cancers in a well-defined population. Dis Colon Rectum 50(10):1568–1575. https://doi.org/10.1007/s10350-007-9007-4

    Article  PubMed  Google Scholar 

  14. Chun YJ, Yoon NR, Park JM, Lim CH, Cho YK, Lee IS, Kim SW, Choi MG, Choi KY, Chung IS (2012) Prospective assessment of risk of bacteremia following colorectal stent placement. Dig Dis Sci 57(4):1045–1049. https://doi.org/10.1007/s10620-011-1962-x

    Article  PubMed  Google Scholar 

  15. Dohmoto M (1991) New method endoscopic implantation of rectal stent in palliative treatment of malignant stenosis. Endosc Digest 3:1507–1512

    Google Scholar 

  16. Frago R, Ramirez E, Millan M, Kreisler E, del Valle E, Biondo S (2014) Current management of acute malignant large bowel obstruction: a systematic review. Am J Surg 207(1):127–138. https://doi.org/10.1016/j.amjsurg.2013.07.027

    Article  PubMed  Google Scholar 

  17. Geraghty J, Sarkar S, Cox T, Lal S, Willert R, Ramesh J, Bodger K, Carlson GL (2014) Management of large bowel obstruction with self-expanding metal stents. A multicentre retrospective study of factors determining outcome. Color Dis 16(6):476–483. https://doi.org/10.1111/codi.12582

    Article  CAS  Google Scholar 

  18. Hartmann H (1923) Note sur un procede nouveau d’extirpation des cancers de la partie du colon. Bull Mem Soc Paris 49:1474–1477

    Google Scholar 

  19. Kim MK, Kye BH, Lee IK, Oh ST, Ahn CH, Lee YS, Lee SC, Kang WK (2017) Outcome of bridge to surgery stenting for obstructive left colon cancer. ANZ J Surg 87(12):E245–E250. https://doi.org/10.1111/ans.13525

    Article  PubMed  Google Scholar 

  20. Kobayashi H, Miyata H, Gotoh M, Baba H, Kimura W, Kitagawa Y, Nakagoe T, Shimada M, Tomita N, Sugihara K, Mori M (2014) Risk model for right hemicolectomy based on 19,070 Japanese patients in the National Clinical Database. J Gastroenterol 49(6):1047–1055. https://doi.org/10.1007/s00535-013-0860-8

    Article  PubMed  Google Scholar 

  21. Malgras B, Brulle L, Lo Dico R, El Marjou F, Robine S, Therwath A, Pocard M (2015) Insertion of a stent in obstructive colon cancer can induce a metastatic process in an experimental murine model. Ann Surg Oncol 22(Suppl 3):S1475–S1480. https://doi.org/10.1245/s10434-015-4588-y

    Article  PubMed  Google Scholar 

  22. Mashar M, Mashar R, Hajibandeh S (2019) Uncovered versus covered stent in management of large bowel obstruction due to colorectal malignancy: a systematic review and meta-analysis. Int J Color Dis 34(5):773–785. https://doi.org/10.1007/s00384-019-03277-3

    Article  Google Scholar 

  23. Mege D, Sabbagh C, Manceau G, Bridoux V, Lakkis Z, Momar D, Sielezneff I, Karoui M, Group AFCW (2019) What is the best option between primary diverting stoma or endoscopic stent as a bridge to surgery with a curative intent for obstructed left colon cancer? Results from a propensity score analysis of the French Surgical Association Multicenter Cohort of 518 patients. Ann Surg Oncol 26(3):756–764. https://doi.org/10.1245/s10434-018-07139-0

    Article  PubMed  Google Scholar 

  24. Nugent KP, Daniels P, Stewart B, Patankar R, Johnson CD (1999) Quality of life in stoma patients. Dis Colon Rectum 42(12):1569–1574. https://doi.org/10.1007/bf02236209

    Article  CAS  PubMed  Google Scholar 

  25. Nyam DC, Seow-Choen F, Leong AF, Ho YH (1996) Colonic decompression without on-table irrigation for obstructing left-sided colorectal tumours. Br J Surg 83(6):786–787. https://doi.org/10.1002/bjs.1800830618

    Article  CAS  PubMed  Google Scholar 

  26. Oistamo E, Hjern F, Blomqvist L, Falken Y, Pekkari K, Abraham-Nordling M (2016) Emergency management with resection versus proximal stoma or stent treatment and planned resection in malignant left-sided colon obstruction. World J Surg Oncol 14(1):232. https://doi.org/10.1186/s12957-016-0994-2

    Article  PubMed  PubMed Central  Google Scholar 

  27. Pirlet IA, Slim K, Kwiatkowski F, Michot F, Millat BL (2011) Emergency preoperative stenting versus surgery for acute left-sided malignant colonic obstruction: a multicenter randomized controlled trial. Surg Endosc 25(6):1814–1821. https://doi.org/10.1007/s00464-010-1471-6

    Article  PubMed  Google Scholar 

  28. Pisano M, Zorcolo L, Merli C, Cimbanassi S, Poiasina E, Ceresoli M, Agresta F, Allievi N, Bellanova G, Coccolini F, Coy C, Fugazzola P, Martinez CA, Montori G, Paolillo C, Penachim TJ, Pereira B, Reis T, Restivo A, Rezende-Neto J, Sartelli M, Valentino M, Abu-Zidan FM, Ashkenazi I, Bala M, Chiara O, De’ Angelis N, Deidda S, De Simone B, Di Saverio S, Finotti E, Kenji I, Moore E, Wexner S, Biffl W, Coimbra R, Guttadauro A, Leppaniemi A, Maier R, Magnone S, Mefire AC, Peitzmann A, Sakakushev B, Sugrue M, Viale P, Weber D, Kashuk J, Fraga GP, Kluger I, Catena F, Ansaloni L (2018) 2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation. World J Emerg Surg 13:36. https://doi.org/10.1186/s13017-018-0192-3

    Article  PubMed  PubMed Central  Google Scholar 

  29. Repici A, De Caro G, Luigiano C, Fabbri C, Pagano N, Preatoni P, Danese S, Fuccio L, Consolo P, Malesci A, D’Imperio N, Cennamo V (2008) WallFlex colonic stent placement for management of malignant colonic obstruction: a prospective study at two centers. Gastrointest Endosc 67(1):77–84. https://doi.org/10.1016/j.gie.2007.08.019

    Article  PubMed  Google Scholar 

  30. Sabbagh C, Browet F, Diouf M, Cosse C, Brehant O, Bartoli E, Mauvais F, Chauffert B, Dupas JL, Nguyen-Khac E, Regimbeau JM (2013) Is stenting as “a bridge to surgery” an oncologically safe strategy for the management of acute, left-sided, malignant, colonic obstruction? A comparative study with a propensity score analysis. Ann Surg 258(1):107–115. https://doi.org/10.1097/SLA.0b013e31827e30ce

    Article  PubMed  Google Scholar 

  31. Sagar J (2016) Role of colonic stents in the management of colorectal cancers. World J Gastrointest Endosc 8(4):198–204. https://doi.org/10.4253/wjge.v8.i4.198

    Article  PubMed  PubMed Central  Google Scholar 

  32. Sloothaak DA, van den Berg MW, Dijkgraaf MG, Fockens P, Tanis PJ, van Hooft JE, Bemelman WA, Collaborative Dutch Stent-In Study G (2014) Oncological outcome of malignant colonic obstruction in the Dutch Stent-In 2 trial. Br J Surg 101(13):1751–1757. https://doi.org/10.1002/bjs.9645

    Article  CAS  PubMed  Google Scholar 

  33. Small AJ, Coelho-Prabhu N, Baron TH (2010) Endoscopic placement of self-expandable metal stents for malignant colonic obstruction: long-term outcomes and complication factors. Gastrointest Endosc 71(3):560–572. https://doi.org/10.1016/j.gie.2009.10.012

    Article  PubMed  Google Scholar 

  34. Smithers BM, Theile DE, Cohen JR, Evans EB, Davis NC (1986) Emergency right hemicolectomy in colon carcinoma: a prospective study. Aust N Z J Surg 56(10):749–752. https://doi.org/10.1111/j.1445-2197.1986.tb02320.x

    Article  CAS  PubMed  Google Scholar 

  35. Takahashi H, Okabayashi K, Tsuruta M, Hasegawa H, Yahagi M, Kitagawa Y (2015) Self-expanding metallic stents versus surgical intervention as palliative therapy for obstructive colorectal cancer: a meta-analysis. World J Surg 39(8):2037–2044. https://doi.org/10.1007/s00268-015-3068-7

    Article  PubMed  Google Scholar 

  36. Takahashi G, Yamada T, Iwai T, Takeda K, Koizumi M, Shinji S, Uchida E (2018) Oncological assessment of stent placement for obstructive colorectal cancer from circulating cell-free DNA and circulating tumor DNA dynamics. Ann Surg Oncol 25(3):737–744. https://doi.org/10.1245/s10434-017-6300-x

    Article  PubMed  Google Scholar 

  37. Tanis PJ, Paulino Pereira NR, van Hooft JE, Consten EC, Bemelman WA, Dutch Surgical Colorectal A (2015) Resection of obstructive left-sided colon cancer at a national level: a prospective analysis of short-term outcomes in 1,816 patients. Dig Surg 32(5):317–324. https://doi.org/10.1159/000433561

    Article  PubMed  Google Scholar 

  38. Tejero E, Mainar A, Fernandez L, Tobio R, De Gregorio MA (1994) New procedure for the treatment of colorectal neoplastic obstructions. Dis Colon Rectum 37(11):1158–1159. https://doi.org/10.1007/bf02049822

    Article  CAS  PubMed  Google Scholar 

  39. Tung KL, Cheung HY, Ng LW, Chung CC, Li MK (2013) Endo-laparoscopic approach versus conventional open surgery in the treatment of obstructing left-sided colon cancer: long-term follow-up of a randomized trial. Asian J Endosc Surg 6(2):78–81. https://doi.org/10.1111/ases.12030

    Article  PubMed  Google Scholar 

  40. van de Wall BJ, Draaisma WA, Consten EC, van der Graaf Y, Otten MH, de Wit GA, van Stel HF, Gerhards MF, Wiezer MJ, Cense HA, Stockmann HB, Leijtens JW, Zimmerman DD, Belgers E, van Wagensveld BA, Sonneveld ED, Prins HA, Coene PP, Karsten TM, Klaase JM, Statius Muller MG, Crolla RM, Broeders IA (2010) Dutch Diverticular Disease (3D) Collaborative Study Group. DIRECT trial. Diverticulitis recurrences or continuing symptoms: Operative versus conservative treatment. A multicenter randomised clinical trial. BMC Surg 10:25

    Google Scholar 

  41. van Halsema EE, van Hooft JE, Small AJ, Baron TH, Garcia-Cano J, Cheon JH, Lee MS, Kwon SH, Mucci-Hennekinne S, Fockens P, Dijkgraaf MG, Repici A (2014) Perforation in colorectal stenting: a meta-analysis and a search for risk factors. Gastrointest Endosc 79(6):970–982.e977; quiz 983.e972, 983.e975. https://doi.org/10.1016/j.gie.2013.11.038

  42. van Hooft JE, Bemelman WA, Oldenburg B, Marinelli AW, Lutke Holzik MF, Grubben MJ, Sprangers MA, Dijkgraaf MG, Fockens P, Collaborative Dutch Stent-In Study G (2011) Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial. Lancet Oncol 12(4):344–352. https://doi.org/10.1016/S1470-2045(11)70035-3

    Article  PubMed  Google Scholar 

  43. van Hooft JE, van Halsema EE, Vanbiervliet G, Beets-Tan RG, DeWitt JM, Donnellan F, Dumonceau JM, Glynne-Jones RG, Hassan C, Jimenez-Perez J, Meisner S, Muthusamy VR, Parker MC, Regimbeau JM, Sabbagh C, Sagar J, Tanis PJ, Vandervoort J, Webster GJ, Manes G, Barthet MA, Repici A, European Society of Gastrointestinal E (2014) Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline. Endoscopy 46(11):990–1053. https://doi.org/10.1055/s-0034-1390700

    Article  PubMed  Google Scholar 

  44. van Hooft JE, Veld JV, Arnold D, Beets-Tan RGH, Everett S, Gotz M, van Halsema EE, Hill J, Manes G, Meisner S, Rodrigues-Pinto E, Sabbagh C, Vandervoort J, Tanis PJ, Vanbiervliet G, Arezzo A (2020) Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) guideline – update 2020. Endoscopy 52(5):389–407. https://doi.org/10.1055/a-1140-3017

    Article  PubMed  Google Scholar 

  45. Veld JV, Amelung FJ, Borstlap WAA, van Halsema EE, Consten ECJ, Siersema PD, Ter Borg F, van der Zaag ES, Fockens P, Bemelman WA, van Hooft JE, Tanis PJ, Dutch Snapshot Research G (2019) Changes in management of left-sided obstructive colon cancer: national practice and guideline implementation. J Natl Compr Cancer Netw 17(12):1512–1520. https://doi.org/10.6004/jnccn.2019.7326

    Article  Google Scholar 

  46. Verstockt B, Van Driessche A, De Man M, van der Spek P, Hendrickx K, Casneuf V, Dobbels P, Van Molhem Y, Vandervoort J (2018) Ten-year survival after endoscopic stent placement as a bridge to surgery in obstructing colon cancer. Gastrointest Endosc 87(3):705–713.e702. https://doi.org/10.1016/j.gie.2017.05.032

    Article  PubMed  Google Scholar 

  47. Webster PJ, Aldoori J, Burke DA (2019) Optimal management of malignant left-sided large bowel obstruction: do international guidelines agree? World J Emerg Surg 14:23. https://doi.org/10.1186/s13017-019-0242-5

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alberto Arezzo .

Editor information

Editors and Affiliations

Section Editor information

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Forcignanò, E., Currado, F., Lo Secco, G., Arezzo, A. (2021). Colorectal Stenting as Bridge to Surgery. In: Testoni, P.A., Inoue, H., Wallace, M.B. (eds) Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-29964-4_58-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-29964-4_58-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-29964-4

  • Online ISBN: 978-3-030-29964-4

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics