Papillary Thyroid Cancer
Pearls and Pitfalls
Papillary thyroid cancer (PTC) accounts for 80% of all thyroid cancers and is the most rapidly increasing cancer in women in the United States.
Latent thyroid cancer is present in 6.2–36% of thyroid glands at autopsy.
Neck ultrasound evaluates the thyroid gland for suspicious nodules, as well as for thyroid cancer metastasis in cervical lymph nodes.
Fine needle aspiration biopsy cytology (FNAC) under ultrasound guidance accurately diagnoses papillary, medullary, and anaplastic thyroid cancer and/or lymph node involvement.
A total or near-total thyroidectomy is indicated for most patients with clinical thyroid cancer greater than 1 cm in size.
Central neck and/or lateral neck dissection is indicated for clinically or scan-positive abnormal lymph nodes.
A nonoperative approach is being done in Japan for patients with isolated micro PTC (≤1 cm) by FNAC without nodal involvement, in whom the tumor is not adjacent to the recurrent laryngeal nerve or trachea....
- American Joint Committee on Cancer (2002) AJCC Cancer Staging Manual, 6th edn. Springer-Verlag, New York, www.springeronline.com
- Cady B, et al. (1998) An expanded view of risk-group definition in differentiated thyroid carcinoma. Surgery 104:947–953 CrossRef
- Caron NR, Clark OH (2004) Well differentiated thyroid cancer. Scand J Surg 93:261–271
- Chan J (2000) Tumors of the thyroid and parathyroid glands. In: Fletcher CDM (ed) Diagnostic histopathology of tumors, 2nd edn. Churchill Livingstone, London
- Cooper DS, Doherty GM, Haugen BR, et al. (2006) Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 16:1–33 CrossRef
- Gilliland FD, Hunt WC, Morris DM, Key CR (1997) Prognostic factors for thyroid carcinoma. A population-based study of 15,698 cases from the Surveillance, Epidemiology and End Results (SEER) program 1973–1991. Cancer 79:564–573 CrossRef
- Hay ID, et al. (1987) Ipsilateral lobectomy versus bilateral lobar resection in papillary thyroid carcinoma: a retrospective analysis of surgical outcome using a novel prognostic scoring system. Surgery 102:1088–1095
- Hay ID, et al. (1989) Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989. Surgery 114:1050–1058
- Ito Y, Uruno T, Nakano K, et al. (2003) An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid. Thyroid 13:381–387 CrossRef
- Kebebew E, et al. (2003) Locally advanced differentiated thyroid cancer. Surg Oncol 12:91–99 CrossRef
- Miyauchi A, Matsusaka K, Kihara M, et al. (1998) The role of ansa-to-recurrent-laryngeal nerve anastomosis in operations for thyroid cancer. Eur J Surg 164(12):927–933 CrossRef
- Pacini F, Ladenson PW, Schlumberger M, et al. (2006) Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study. J Clin Endocrinol Metab 91:926–932 CrossRef
- Pujol P, Daures JP, Nsakala N, Baldet L, Bringer J, Jaffiol C (1996) Degree of thyrotropin suppression as a prognostic determinant in differentiated thyroid cancer. J Clin Endocrinol Metab 81:4318–4323 CrossRef
- Tomoda C, Miyauchi A, Uruno T, et al. (2004) Cribriform-morular variant of papillary thyroid carcinoma: clue to early detection of familial adenomatous polyposis-associated colon cancer. World J Surg 28(9):886–889 CrossRef
- Treseler PA (1997) Prognostic factors in thyroid carcinoma. Surg Oncol Clin North Am 6:555–598
- Uruno T, Miyauchi A, Shimizu K, et al. (2005) Favorable surgical results in 433 elderly patients with papillary thyroid cancer. World J Surg 29:1497–1501; discussion 502–503 CrossRef
- Uruno T, Miyauchi A, Shimizu K, et al. (2004) Prognosis after reoperation for local recurrence of papillary thyroid carcinoma. Surg Today 34:891–895 CrossRef
- Uruno T, Miyauchi A, Shimizu K, et al. (2005) Usefulness of thyroglobulin measurement in fine-needle aspiration biopsy specimens for diagnosing cervical lymph node metastasis in patients with papillary thyroid cancer. World J Surg 29:483–485 CrossRef
- Wada N, Duh QY, Sugino K, et al. (2003) Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection. Ann Surg 237:399–407
- Wang HH (2006) Reporting thyroid fine-needle aspiration: literature review and a proposal. Diagn Cytopathol 34:67–76 CrossRef
- Papillary Thyroid Cancer
- Reference Work Title
- General Surgery
- Reference Work Part
- Section 8
- pp 1643-1650
- Print ISBN
- Online ISBN
- Springer London
- Copyright Holder
- Springer-Verlag London
- Additional Links
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- Editor Affiliations
- 1. Department of Surgery, Deputy Director, Comprehensive Cancer Center University of Alabama School of Medicine
- 2. Department of General and Visceral Surgery, University of Heidelberg
- 3. Department of Surgery, University Hospital
- 4. James C. Mason Professor of Surgery Department of Surgery, Mayo Clinic College of Medicine
- 5. Department of Clinical and Surgical Sciences, The University of Edinburgh Royal Infirmary of Edinburgh
- 6. Department of Surgery, The University of Hong Kong Queen Mary Hospital
- Author Affiliations
- 1. Department of Surgery, University of California San Francisco and UCSF/Mt. Zion Medical Center, 1600 Divisadero Street, #C347, San Francisco, CA, 94115, USA
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