Definition
Cytoadhesion in malaria is the ability of the parasite to adhere to endothelial cell receptors. Cytoadhesion during pregnancy may occur at the placenta where the Plasmodium parasites can adhere to CSA receptors.
Introduction
Adult women living in a malaria-endemic area are more susceptible to malaria symptomatic disease during the first pregnancy. Although severe malaria is more common during the first years in life, malaria during pregnancy, especially in the first pregnancy, is a peculiar case. Malaria in pregnancy can cause severe disease to the mother and to the fetus. Severe maternal anemia and low birth weight babies are some consequences of malaria in pregnancy (Brabin 1983).
The sequestration of the parasite in the placenta is a mechanism that protects the parasite from being eliminated by the spleen. On the other hand, for the host, the sequestration of infected...
References
Albrecht L, Castiñeiras C, Carvalho BO, Ladeia-Andrade S, SantosdaSilva N, Hoffmann EHE, et al. The South American Plasmodium falciparum var gene repertoire is limited, highly shared and possibly lacks several antigenic types. Gene. 2010;453(1–2):37–44.
Bernabeu M, Lopez FJ, Ferrer M, Martin-Jaular L, Razaname A, Corradin G, et al. Functional analysis of Plasmodium vivax VIR proteins reveals different subcellular localizations and cytoadherence to the ICAM-1 endothelial receptor. Cell Microbiol. 2012;14(3):386–400.
Bordbar B, Tuikue-Ndam N, Bigey P, Doritchamou J, Scherman D, Deloron P. Identification of Id1-DBL2X of VAR2CSA as a key domain inducing highly inhibitory and cross-reactive antibodies. Vaccine. 2012;30(7):1343–8.
Brabin BJ. An analysis of malaria in pregnancy in Africa. Bull World Health Organ. 1983;61(6):1005–16.
Brolin KJM, Ribacke U, Nilsson S, Ankarklev J, Moll K, Wahlgren M, et al. Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites. Genome Biol. 2009;10(10):R117.
Bull PC, Lowe BS, Kortok M, Molyneux CS, Newbold CI, Marsh K. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria. Nat Med. 1998;4(3):358–60.
Carvalho BO, Lopes SCP, Nogueira PA, Orlandi PP, Bargieri DY, Blanco YC, et al. On the cytoadhesion of Plasmodium vivax-infected erythrocytes. J Infect Dis. 2010;202(4):638–47.
Cham GKK, Turner L, Kurtis JD, Mutabingwa T, Fried M, Jensen ATR, et al. Hierarchical, domain type-specific acquisition of antibodies to Plasmodium falciparum erythrocyte membrane protein 1 in Tanzanian children. Infect Immun. 2010;78(11):4653–9.
Chotivanich K, Udomsangpetch R, Suwanarusk R, Pukrittayakamee S, Wilairatana P, Beeson JG, et al. Plasmodium vivax adherence to placental glycosaminoglycans. PLoS One. 2012;7(4), e34509.
Doritchamou J, Bertin G, Moussiliou A, Bigey P, Viwami F, Ezinmegnon S, et al. First-trimester Plasmodium falciparum infections display a typical « placental » phenotype. J Infect Dis. 2012;206(12):1911–9.
Doritchamou J, Bigey P, Nielsen M, Gnidehou S, Ezinmegnon S, Burgain A, et al. Differential adhesion-inhibitory patterns of antibodies raised against two major variants of the NTS-DBL2X region of VAR2CSA. Vaccine. 2013;31:4516–22.
Druilhe P, Hagan P, Rook GAW. The importance of models of infection in the study of disease resistance. Trends Microbiol. 2002;10(10 Suppl):S38–46.
Duffy PE, Fried M. Plasmodium falciparum adhesion in the placenta. Curr Opin Microbiol. 2003;6(4):371–6.
Field JW, Sandosham AA, Fong YL. A morphological study of the erythrocytic parasites in thick blood films. In: The microscopic diagnosis of human malaria. Kuala Lumpur: The Government Press; 1963. p. 20–117.
Fried M, Duffy PE. Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta. Science. 1996;272(5267):1502–4.
Fried M, Nosten F, Brockman A, Brabin BJ, Duffy PE. Maternal antibodies block malaria. Nature. 1998;395(6705):851–2.
Hall N, Carlton J. Comparative genomics of malaria parasites. Curr Opin Genet Dev. 2005;15(6):609–13.
Hviid L, Marinho CRF, Staalsoe T, Penha-Gonçalves C. Of mice and women: rodent models of placental malaria. Trends Parasitol. 2010;26(8):412–9.
Lavstsen T, Turner L, Saguti F, Magistrado P, Rask TS, Jespersen JS, et al. Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children. Proc Natl Acad Sci U S A. 2012;109(26):E1791–800.
Magistrado PA, Minja D, Doritchamou J, Ndam NT, John D, Schmiegelow C, et al. High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women. Vaccine. 2011;29(3):437–43.
Marín-Menéndez A, Bardají A, Martínez-Espinosa FE, Bôtto-Menezes C, Lacerda MV, Ortiz J, et al. Rosetting in Plasmodium vivax: a cytoadhesion phenotype associated with anaemia. PLoS Negl Trop Dis. 2013;7(4), e2155.
Miller LH, Baruch DI, Marsh K, Doumbo OK. The pathogenic basis of malaria. Nature. 2002;415(6872):673–9.
Neres R, Marinho CRF, Gonçalves LA, Catarino MB, Penha-Gonçalves C. Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women. PLoS One. 2008;3(2), e1608.
Rogerson SJ, Katundu P, Molyneux ME. Rosette formation by clinical isolates of Plasmodium falciparum in serum-free medium. Trans R Soc Trop Med Hyg. 2000;94(4):461–2.
Rogerson SJ, Mwapasa V, Meshnick SR. Malaria in pregnancy: linking immunity and pathogenesis to prevention. Am J Trop Med Hyg. 2007;77(6 Suppl):14–22.
Rowe A, Obeiro J, Newbold CI, Marsh K. Plasmodium falciparum rosetting is associated with malaria severity in Kenya. Infect Immun. 1995;63(6):2323–6.
Russell B, Suwanarusk R, Borlon C, Costa FTM, Chu CS, Rijken MJ, et al. A reliable ex vivo invasion assay of human reticulocytes by Plasmodium vivax. Blood. 2011;118(13):e74–81.
Salanti A, Staalsoe T, Lavstsen T, Jensen ATR, Sowa MPK, Arnot DE, et al. Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria. Mol Microbiol. 2003;49(1):179–91.
Souza RM, Ataíde R, Dombrowski JG, Ippólito V, Aitken EH, Valle SN, et al. Placental histopathological changes associated with Plasmodium vivax infection during pregnancy. PLoS Negl Trop Dis. 2013;7(2), e2071.
Steketee RW, Nahlen BL, Parise ME, Menendez C. The burden of malaria in pregnancy in malaria-endemic areas. Am J Trop Med Hyg. 2001;64(1–2 Suppl):28–35.
Takem EN, D’Alessandro U. Malaria in pregnancy. Mediterr J Hematol Infect Dis. 2013;5(1), e2013010.
Taylor TE, Fu WJ, Carr RA, Whitten RO, Mueller JS, Fosiko NG, et al. Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nat Med. 2004;10(2):143–5.
Trimnell AR, Kraemer SM, Mukherjee S, Phippard DJ, Janes JH, et al. Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria. Mol Biochem Parasitol. 2006;148:169–180.
Tuikue Ndam NG, Fievet N, Bertin G, Cottrell G, Gaye A, Deloron P. Variable adhesion abilities and overlapping antigenic properties in placental Plasmodium falciparum isolates. J Infect Dis. 2004;190(11):2001–9.
Tuikue Ndam NG, Salanti A, Bertin G, Dahlbäck M, Fievet N, Turner L, et al. High level of var2csa transcription by Plasmodium falciparum isolated from the placenta. J Infect Dis. 2005;192(2):331–5.
Turner L, Lavstsen T, Berger SS, Wang CW, Petersen JEV, Avril M, et al. Severe malaria is associated with parasite binding to endothelial protein C receptor. Nature. 2013;498:502–505.
Author information
Authors and Affiliations
Corresponding authors
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this entry
Cite this entry
Costa, F.T.M., Albrecht, L., Ndam, N.T. (2015). Physiopathology of Malaria During Pregnancy: Adhesion and Sequestration Phenotypes of Malaria Infection. In: Hommel, M., Kremsner, P. (eds) Encyclopedia of Malaria. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8757-9_66-1
Download citation
DOI: https://doi.org/10.1007/978-1-4614-8757-9_66-1
Received:
Accepted:
Published:
Publisher Name: Springer, New York, NY
Online ISBN: 978-1-4614-8757-9
eBook Packages: Springer Reference MedicineReference Module Medicine