Historical Background
The Src Homology 2 (SH2) domain-containing adaptor proteins are a class of signal transducers downstream of growth factor receptors. The human genome encodes more than one hundred SH2 domain-containing proteins. The GRB7 family of SH2 domain-containing adaptor proteins includes three members: GRB7, GRB10, and GRB14. All three family members have the same domain structure (Fig. 1). Human GRB10 was originally identified in a yeast-two hybrid screen using the insulin receptor (IR) as bait and named as GRB-IR (Liu and Roth 1995).
GRB7 family proteins share similar domains.GRB7 family proteins share a similar domain arrangement. An N-terminal still un-characterized region followed by a RAS-associated like (RA) domain, which is known to bind with RAS superfamily proteins. The pleckstrin homology (PH) domain binds to phospholipids and recruits proteins to the cell membrane. The Src Homology 2 (SH2) domain is a...
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Kabir, N.N., Rönnstrand, L., Kazi, J.U. (2016). GRB10. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101665-1
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DOI: https://doi.org/10.1007/978-1-4614-6438-9_101665-1
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