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Quasi-Elastic Light Scattering in Ophthalmology

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Handbook of Coherent-Domain Optical Methods

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Abstract

The eye is not just a “window to the soul”; it can also be a “window to the human body.” The eye is built like a camera. Light which travels from the cornea to the retina traverses through tissues that are representative of nearly every tissue type and fluid type in the human body. Therefore, it is possible to diagnose ocular and systemic diseases through the eye. Quasi-elastic light scattering (QELS) also known as dynamic light scattering (DLS) is a laboratory technique routinely used in the characterization of macromolecular dispersions. QELS instrumentation has now become more compact, sensitive, flexible, and easy to use. These developments have made QELS/DLS an important tool in ophthalmic research where disease can be detected early and noninvasively before the clinical symptoms appear.

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Acknowledgments

The author would like to thank Dr. Valery Tuchin for inviting him to write this chapter. He is also indebted to many colleagues and collaborators with whom experiments reported in this chapter were conducted. These include Sam Zigler and Manuel Datiles of NEI/NIH in Bethesda, MD, for animal and clinical cataract studies, Luigi Rovati of the University of Modena in Italy for glaucoma studies, John Clark of the University of Washington in Seattle for pantethine treatment, Frank Giblin of the Oakland University in MI for guinea pig HBO and rabbit X-ray studies, Michelle Chenault of FDA, Rockville Pike in MD for studies on diabetic sand rats, Jerry Sebag of Doheny Eye Institute in Los Angeles, CA, for vitreopathy studies, Kwang Suh and Jim King of the author’s laboratory for new instrument development, and Su-Long Nyeo of the Cheng Kung University in Taiwan for new software development. The support under NASA-NIH and NASA-FDA interagency agreements on the development and use of QELS/DLS in ophthalmology and funding from the John H. Glenn Biomedical Engineering Consortium for the bioastronautics research are greatly appreciated.

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  1. NASA John H. Glenn Research Center at Lewis Field, 21000 Brookpark Road, 110-2, Cleveland, OH, 44135, USA

    Rafat R. Ansari

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  1. Rafat R. Ansari
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Correspondence to Rafat R. Ansari .

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  1. , Chair of Optics and Biophotonics, Saratov State University, Astrakhanskaya str. 83, Saratov, 410012, Russia

    Valery V. Tuchin

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Ansari, R.R. (2013). Quasi-Elastic Light Scattering in Ophthalmology. In: Tuchin, V. (eds) Handbook of Coherent-Domain Optical Methods. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5176-1_14

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