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Animal Models in Rheumatoid Arthritis

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Encyclopedia of Medical Immunology

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Synonyms

Inflammatory arthritis animal model

Definition

Rheumatoid arthritis is the most common form of inflammatory joint disease and is characterized by synovial hyperplasia, immune cell infiltration, pannus formation, cartilage destruction, and bone erosion. A variety of animal models of arthritis have been established, including those that involve the injection of TNF-alpha, proteoglycan, adjuvant, antibody, or collagen. These animal models demonstrate synovitis, pannus formation, bone and cartilage destruction, as well as other features observed in human rheumatoid arthritis. They provide a useful platform to investigate the pathogenesis and determine the effects of novel therapies for rheumatoid arthritis.

Rheumatoid Arthritis

Rheumatoid arthritis is the most common form of inflammatory arthritis and is characterized by synovial hyperplasia, immune cell infiltration, pannus formation, cartilage destruction, and bone erosion (Feldmann and Maini 2003). In the inflamed synovial...

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, Nanjing Medical University, 140 Hanzhong road, Nanjing, Jiangsu, 210029, China

    Guo-Min Deng

Authors
  1. Guo-Min Deng
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Corresponding author

Correspondence to Guo-Min Deng .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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© 2014 Springer Science+Business Media New York

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Deng, GM. (2014). Animal Models in Rheumatoid Arthritis. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_359

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_359

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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