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Autoimmune Heart Disease: Animal Models

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Encyclopedia of Medical Immunology

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Definition

Autoimmune heart disease defines any structural or functional alteration of heart tissue due to aberrant immune responses against cardiac self-antigens, which impairs the capacity of the heart to maintain sufficient cardiac output to meet metabolic demands of the body. The term autoimmune myocarditis specifies cardiac inflammation due to an autoimmune response. Of note, autoimmune heart disease can also be part of a general self-reactive process involving other organ systems as well. This entry, however, focuses exclusively on animal models, which (1) mirror heart-specific autoimmunity only, and (2) on animal models in which self-antigen exposure but not infection trigger autoimmunity.

Introduction

During the past several years, autoimmune mechanisms had been increasingly recognized to be involved in the development of almost all cardiac diseases, such as dilated or structural cardiomyopathy, valvular heart disease, coronary arterial disease, hypertensive heart failure, and...

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, GZO – Zurich Regional Health Center, Spitalstrasse 66, Wetzikon, Switzerland

    Urs Eriksson

  2. Division of Cardioimmunology, Department of Cardiovascular Research, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland

    Urs Eriksson

Authors
  1. Urs Eriksson
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Correspondence to Urs Eriksson .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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Eriksson, U. (2014). Autoimmune Heart Disease: Animal Models. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_190

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_190

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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