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Molecular Genetics of Brain Noradrenergic Neurotransmission

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Handbook of Neurochemistry and Molecular Neurobiology

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Abstract:

The brain noradrenergic system plays a pivotal role in mediating the responses of the organism to the external and internal milieu and particularly to stress. The different components of this system have been implicated in a wide range of normal and pathological behavior. Recent advances in molecular psychiatric genetics may pave the way for a better understanding of the etiology of different symptoms of mental diseases and their relationship to environmental factors.

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Abbreviations

AAD:

Aromatic Amino acid Decarboxylase

AC:

adenylyl cyclase

ADs:

antidepressant drugs

BMP:

Bone Morphogenetic Proteins

COMT:

catechol-O-methyltransferase

DAG:

diacylglycerol

DOPA:

3,4 dihydroxyphenylalanine

DHPG:

3,4-dihydroxyphenyl-glycol

MHPG:

3-methoxy-4-hydroxyphenylglycol

fmri:

functional magnetic resonance imaging

Gata3:

GATA-binding protein 3

GDP:

guanosine diphosphate

GPCRs:

G protein-coupled receptors

GTP:

guanosine triphosphate

HPA:

hypothalamic-pituitary-adrenal

LC:

Locus Coeruleus

MAOs:

monoamineoxidases

NET:

NE transporter

PKC:

protein kinase C

PKA:

protein kinases A

PNMT:

Phenylethanolamine-N-Methyl-Transferase

PLC:

phospholipase C

PTSD:

posttraumatic stress disorder

SSRIs:

selective serotonin reuptake inhibitors

TH:

Tyrosine Hydroxylase

VMA:

vanyl-mandelic acid

VCF:

velocardiofacial syndrome

VMAT:

vesicular monoamine transporter

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  1. R. Meloni
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  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 10962, 140 Old Orangeburg Road, Orangeburg, New York, USA

    Abel Lajtha (Director) (Director)

  2. Institute of Experimental Medicine, Hungarian Academy of Sciences, 43, H-1083 Budapest, Szigony, Hungary

    E. Sylvester Vizi

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Meloni, R. (2008). Molecular Genetics of Brain Noradrenergic Neurotransmission. In: Lajtha, A., Vizi, E.S. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30382-6_6

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