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Structure of IP3 Receptor

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Handbook of Neurochemistry and Molecular Neurobiology

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Abstract

The inositol 1,4,5-trisphosphate receptor (IP3R) is an intracellular tetrameric calcium (Ca2+)-release channel localized predominantly on the endoplasmic reticulum of all cell types. IP3R releases Ca2+ into the cytoplasm in response to inositol 1,4,5-trisphosphate (IP3) produced by diverse stimuli, generating complex local and global Ca2+ signals that regulate numerous cell physiological processes, including gene transcription, secretion, and synaptic plasticity (see Chapter 25). This versatility is derived from the diverse properties of IP3R. Three IP3R isoforms in mammals and a single isoform in invertebrates are expressed with several splice variants. Though they have conserved functional domains, IP3R channel activity is regulated in an isoform-specific manner by IP3 and other ligands, such as Ca2+ and ATP, and also by multiple interacting proteins. Recent biochemical, electrophysiological, and structural analyses have deepened our understanding of the functional properties of IP3R. Herein, we review the genetic and functional structures of IP3R and discuss the functional diversity of IP3R isoforms.

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Acknowledgments

We gratefully acknowledge Drs. Mitsuhiko Ikura, Chikara Sato, Yoshinori Fujiyoshi, and their laboratory members for their collaboration in the structural analyses. We also thank the many colleagues whose names are cited in the references. The research in our laboratory is supported by grants from the Japan Science and Technology Agency (KM) and by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (KM).

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  1. H. Yamazaki
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  2. K. Mikoshiba
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Editors and Affiliations

  1. Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, 10962, 140 Old Orangeburg Road, Orangeburg, New York, USA

    Abel Lajtha (Director) (Director)

  2. Group Director of Neuro-Developmental Disorder Research Group, RIKEN Brain Science Institute, 351-0198, 2-1 Hirosawa Wako-shi, Saitama, Japan

    Katsuhiko Mikoshiba

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Yamazaki, H., Mikoshiba, K. (2009). Structure of IP3 Receptor. In: Lajtha, A., Mikoshiba, K. (eds) Handbook of Neurochemistry and Molecular Neurobiology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-30370-3_24

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