Definition
Adenylyl or adenylate cyclase is the critical enzyme in the formation of cyclic adenosine monophosphate (cAMP). Various isoforms exist, they represent a ubiquitous group of enzymes that catalyse the formation of the second messenger cAMP from ATP. The substrate of the reaction is ATP into which a 3′-5′ link via phosphodiester bonds is introduced to form cAMP. The various mammalian isoforms are differentially regulated through G-protein α-subunits and βγ-complexes as well as by Ca2+ or protein kinase C.
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© 2001 Springer-Verlag
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(2001). Adenylyl Cyclase. In: Schwab, M. (eds) Encyclopedic Reference of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30683-8_28
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DOI: https://doi.org/10.1007/3-540-30683-8_28
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-66527-4
Online ISBN: 978-3-540-30683-2
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