Definition
An adenoviral vector is a gene transfer vehicle based on adenovirus, used to deliver genes into host cells.
A first-generation adenoviral vector is characterized by the deletion of the E1A and E1B genes that are the first genes to be expressed from a wild type adenovirus.
A second-generation adenoviral vector is characterized by the deletion of the E1A and E1B genes plus the E2 and/or E4 gene.
A high-capacity adenoviral vector is the most advanced adenoviral vector; the only viral elements that are retained on the vector genome are the adenoviral ends that contain the origin of replication and the packaging signal.
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© 2001 Springer-Verlag
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(2001). Adenoviral Vector. In: Schwab, M. (eds) Encyclopedic Reference of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30683-8_26
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DOI: https://doi.org/10.1007/3-540-30683-8_26
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-66527-4
Online ISBN: 978-3-540-30683-2
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