1 Introduction
Pharmacokinetics (PK) is generally thought as what the body does to the drug, whereas pharmacodynamics (PD) is thought of as what the drug does to the body. When used independently of each other, valuable information can be derived. For example, pharmacokinetic characterization of a drug can quantitatively describe the drug concentration versus time profile and modeling of this profile can result in determination of key pharmacokinetic parameters such as half-life, volume of distribution, clearance, etc. Similarly, pharmacodynamic characterization of a drug quantitatively describes the modulation of a given effect as a function of time. When PK and PD are used in concert, descriptive information on concentration versus effect relationships can be obtained (Levy 1964, 1966, 1994a, b). Knowledge derived using PK/PD relationships PK/PD relationships or exposure/response relationships can be used objectively to support many drug discovery and development decisions....
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Rebello, S., Krishna, R. (2006). Typical PK/PD Approaches. In: Vogel, H.G., Hock, F.J., Maas, J., Mayer, D. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29804-5_38
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DOI: https://doi.org/10.1007/3-540-29804-5_38
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