1 I.J.1. General Considerations
Morphine, as the prototype of a central analgesic drug, has characteristic adverse effects that are relevant to the treatment of patients. Important among these effects are the following:
Respiratory depression,
Decrease of body temperature,
Tolerance,
Physical dependence,
Abuse liability.
Since the ratio between therapeutic effect and adverse effects varies among opioids, great effort has been made to synthesize compounds with a better ratio of antinociceptive activity versus adverse side effects. This effort to discover better, safer compounds necessitated the development of laboratory methods that are sensitive to and, therefore, could be used to quantify the adverse effects of opioids. Moreover, the discovery of several distinct types of receptors that can interact with opioids or with endogenous peptides (e.g. μ, κ, and δ receptor) allows a more selective classification of agonists and antagonists.
2 I.J.2. Test for Respiratory Depression
2.1 Purpose...
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France, C. (2006). Side Effects of Central Analgesic Drugs. In: Vogel, H.G., Hock, F.J., Maas, J., Mayer, D. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29804-5_10
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