Synonym(s)
Pink disease
Definition
Multisystem disease related to mercury intoxication
Pathogenesis
Sympathovasomotor dysfunction secondary to mercury intoxication, perhaps on an idiosyncratic basis
Clinical manifestation
Pain in the hands and feet; hyperhidrosis; excess salivation; gingivitis; early tooth loss; pink discoloration of the nose and distal digits; peripheral neuronitis; hypotonia of the muscles; renal insufficiency
Differential diagnosis
Acrocyanosis; chilblains; acrodermatitis enteropathica; glucagonoma syndrome Kawasaki disease; polio; intoxication with thallium, copper, arsenic, or gold
Therapy
Removal of source of mercury from the environment; DMSA (meso 2,3-dimercaptosuccinic acid) used as a chelating agent; hemodialysis or peritoneal dialysis for renal insufficiency
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References
Graeme KA, Pollack CV Jr (1998) Heavy metal toxicity, Part I: arsenic and mercury. Journal of Emergency Medicine 16(1):45–56
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© 2004 Springer-Verlag
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(2004). Acrodynia. In: Levine, N., Levine, C.C. (eds) Dermatology Therapy. A to Z Essentials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29668-9_63
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DOI: https://doi.org/10.1007/3-540-29668-9_63
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-00864-4
Online ISBN: 978-3-540-29668-3
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