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Modeling Techniques in Epidermal Wound Healing

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Computational Methods in Biophysics, Biomaterials, Biotechnology and Medical Systems

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12.1 3.1 Introduction

A wound can be defined as a disruption of unity in the body where tissue is damaged by a cut or by a tear. The process of repairing a wound is rather complex and it involves many different types of cells. Wound healing has been most closely studied in the skin, which is the largest organ with the most obvious function to protect the body from infectious organisms and toxic chemicals.

Mammalian skin is made up of three regions: the epidermis, the dermis, and the subcutaneous tissue [39,45]. The simplest situation of a wound occurring on the skin is created by a cut through the epidermis into the dermis [39]. The epidermis consists of several layers of cells interlocked into a tight membrane that covers the entire skin surface. The surface cells of the skin, called keratinocytes, have the capacity to protect the skin. These cells eventually die and come off the skin surface, but the cells at the bottom layer of the epidermis go through mitosis to renew the cells...

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  1. Cornelius T. Leondes
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Leondes, C.T. (2003). Modeling Techniques in Epidermal Wound Healing. In: Leondes, C.T. (eds) Computational Methods in Biophysics, Biomaterials, Biotechnology and Medical Systems. Springer, Boston, MA. https://doi.org/10.1007/0-306-48329-7_12

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  • DOI: https://doi.org/10.1007/0-306-48329-7_12

  • Publisher Name: Springer, Boston, MA

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