Reference Work Entry

Glycoscience: Biology and Medicine

pp 1029-1036

Date:

New Aspects of Collectin Functions

  • Katsuki OhtaniAffiliated withDepartment of Microbiology and Immunochemistry, Asahikawa Medical University
  • , Yasuhiko SuzukiAffiliated withDivision of Bioresources, Hokkaido University Research Center for Zoonosis Control
  • , Nobutaka WakamiyaAffiliated withDepartment of Microbiology and Immunochemistry, Asahikawa Medical University Email author 

Abstract

Collectin is a very unique protein, which has two characteristic domains: a collagen-like sequence and carbohydrate recognition domain (CRD). It is considered as a receptor recognizing a pathogen with associated molecular patterns (PAMPs) that play an important role in innate immunity. Recently, it was demonstrated that several collectins can not only activate the complement pathway but are also involved in various biological functions different from a host defense. In this chapter, we focus on “complement activation-related collectins,” consisting of mannan-binding lectin (MBL), complement 1q (C1q), collectin kidney 1 (CL-K1), and collectin placenta 1 (CL-P1), and summarize and discuss various new aspects of their functions.

Keywords

Collectin MASP Complement Collagen Virus Transplantation Innate immunity