Abstract
Collectin is a very unique protein, which has two characteristic domains: a collagen-like sequence and carbohydrate recognition domain (CRD). It is considered as a receptor recognizing a pathogen with associated molecular patterns (PAMPs) that play an important role in innate immunity. Recently, it was demonstrated that several collectins can not only activate the complement pathway but are also involved in various biological functions different from a host defense. In this chapter, we focus on “complement activation-related collectins,” consisting of mannan-binding lectin (MBL), complement 1q (C1q), collectin kidney 1 (CL-K1), and collectin placenta 1 (CL-P1), and summarize and discuss various new aspects of their functions.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Agostinis C, Bulla R, Tripodo C et al (2010) An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development. J Immunol 185:4420–4419
Aramini B, Kim C, DiAngelo S et al (2013) Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome. Am J Transplant 13:2130–2136
Fukuda M, Ohtani K, Jang S-J et al (2011) Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P1. Biochim Biophys Acta 1810:1150–1159
Job ER, Deng YM, Tate MD et al (2010) Pandemic H1N1 influenza A viruses are resistant to the antiviral activities of innate immune proteins of the collectin and pentraxin superfamilies. J Immunol 185:4284–4291
Kase T, Suzuki Y, Kawai T et al (1999) Human mannan-binding lectin inhibits the infection of influenza A virus without complement. Immunology 97:385–392
Ling MT, Tu W, Han Y et al (2012) Mannose-binding lectin contributes to deleterious inflammatory response in pandemic H1N1 and avian H9N2 infection. J Infect Dis 205:44–53
Munster JM, van der Bij W, Breukink MB et al (2008) Association between donor MBL promoter haplotype and graft survival and the development of BOS after lung transplantation. Transplantation 86:1857–1863
Ohtani K, Suzuki Y, Wakamiya N (2012) Biological functions of the novel collectins CL-L1, CL-K1, and CL-P1. J Biomed Biotechnol 2012:493945
Rooryck C, Diaz-Font A, Osborn DP, Chabchoub E et al (2011) Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nat Genet 43:197–203
Takahashi K, Ohtani K, Moyo P, et al. (2014) Elevated plasma CL-K1 levels are associated with a risk of disseminated intravascular coagulation (DIC). J Thromb Thrombolysis. [Epub]
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Japan
About this entry
Cite this entry
Ohtani, K., Suzuki, Y., Wakamiya, N. (2015). New Aspects of Collectin Functions. In: Taniguchi, N., Endo, T., Hart, G., Seeberger, P., Wong, CH. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54841-6_61
Download citation
DOI: https://doi.org/10.1007/978-4-431-54841-6_61
Received:
Accepted:
Published:
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54840-9
Online ISBN: 978-4-431-54841-6
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences