Definition
Porous silicon (PSi) refers to a material containing interconnected networks of empty holes (pores) in a Si structure, rendering the material with a large surface-to-volume ratio properties. PSi materials are classified according to pore diameter, that can vary from a few nanometers to a few micrometers depending on the fabrication parameters. Most commonly, the PSi structure is referred as mesoporous (pores with diameters between 2 and 50 nm). Sometimes the word “nanoporous” is used instead of mesopores to emphasize the nanometric dimension of the pores. The volumetric fraction of empty space (voids) in the structure of the material is called porosity. The internal surface area of PSi per volume unit can be as large as 500 m2/cm3 and can act as reservoirs for storing therapeutic compounds for drug delivery applications.
Fabrication Procedures and Role in Drug Delivery...
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References
Bimbo LM, Sarparanta M, Santos HA et al (2010) Biocompatibility of thermally hydrocarbonized porous silicon nanoparticles and their biodistribution in rats. ACS Nano 4:3023–3032
Bimbo LM, Mäkilä E, Raula J et al (2011) Functional hydrophobin-coating of thermally hydrocarbonized porous silicon microparticles. Biomaterials 32:9089–9099
Canham LT (ed) (1997) Properties of porous silicon. Short Run Press, London
Godin B, Tasciotti E, Liu X et al (2011) Multistage nanovectors: from concept to novel imaging contrast agents and therapeutics. Acc Chem Res 44:979–989
Heinrich JL, Curtis CL, Credo GM, Kavanagh KL, Sailor MJ (1992) Luminescent colloidal silicon suspensions from porous silicon. Science 255:66–68
Kilpeläinen M et al (2009) In vivo delivery of a peptide, ghrelin antagonist, with mesoporous silicon microparticles. J Control Release 37:166–170
Kovalainen M, Mönkäre J, Mäkilä E et al (2011) Mesoporous silicon (PSi) for sustained peptide delivery: effect of PSi microparticle surface chemistry on peptide YY3-36 release. Pharm Res 29:837–846
Lehto V-P, Salonen J, Santos HA, Riikonen J (2012) In: Douroumis D, Fahr A (eds) Nanostructured silicon based materials as a drug delivery system for insoluble drugs. Wiley-Blackwell, Weinheim
Sailor MJ (ed) (2011) Porous silicon in practice: preparation, characterization and applications. Wiley-VCH, Weinheim
Salonen J, Kaukonen AM, Hirvonen J, Lehto V-P (2008) Mesoporous silicon in drug delivery applications. J Pharm Sci 97:632–653
Santos HA, Riikonen J, Salonen J et al (2010) In vitro cytotoxicity of porous silicon microparticles: effect of the particle concentration, surface chemistry and size. Acta Biomater 6:2721–2731
Santos HA, Bimbo LM, Lehto V-P et al (2011) Multifunctional porous silicon for therapeutic drug delivery and imaging. Curr Drug Discov Techol 8:228–249
Sarparanta M, Mäkilä E, Heikkilä T et al (2011) 18F-labeled modified porous silicon particles for investigation of drug delivery carrier distribution in vivo with positron emission tomography. Mol Pharmaceutics 8:1799–1806
Sarparanta MP, Bimbo LM, Mäkilä EM et al (2012) The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems. Biomaterials 33:3353–3362
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Santos, H.A., Salonen, J., Bimbo, L.M. (2013). Porous Silicon for Drug Delivery. In: Kretsinger, R.H., Uversky, V.N., Permyakov, E.A. (eds) Encyclopedia of Metalloproteins. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1533-6_447
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