Criss-Cross Inheritance

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Criss-cross inheritance is characteristic for X-chromosome linked recessive mutations. The recessive genes follow the pattern of inheritance of the X chromosome; they are expressed in the hemizygous male but only in the homozygous female (see Fig. C182).Figure C182.

Criss-cross inheritance

In case the female is heterogametic and the male is homogametic, like in the Lepidoptera or birds, the inheritance follows the mirror image of what is shown in the diagram. sex linkage diagram

Criss-cross inheritance can be observed in humans as well. All the offspring of a red–green color-blind father is expected to be normal but all the male children of a color-blind mother are expected to be affected. Some of the male grandchildren of color-blind grandfathers will be color-blind, although their sons (the fathers of the grandsons) have normal vision.