Virion
Morphology: |
Icosahedral, double-layered capsid |
Envelope: |
No |
Diameter (nm): |
80–90 |
Length (nm): |
– |
Structural components: |
dsRNA genome, T = 1 inner (core) capsid, T = 13 outer capsid |
Buoyant density (g/mL): |
1.36 |
Buoyant density method: |
CsCl |
Lipid composition: |
N-terminal myristoyl modification of outer-capsid protein mu1 |
Additional information: |
dsRNA genome is packed with locally parallel strands; transcriptase complexes project into the genome area from the fivefold axes of the inner capsid; receptor-binding protein fibers (when present) project out from the fivefold axes of the outer capsid |
Genome
Nucleic acid: |
RNA |
|
Strandedness: |
Double-stranded |
|
Polarity: |
– |
|
Configuration: |
Linear |
|
Segment organization: |
Segment no. 1 (kb): |
3.9 |
Segment no. 2 (kb): |
3.9 |
|
Segment no. 3 (kb): |
3.9 |
|
Segment no. 4 (kb): |
2.3 |
|
Segment no. 5 (kb): |
2.2 |
|
Segment no. 6 (kb): |
2.2 |
|
Segment no. 7 (kb): |
1.4 |
|
Segment no. 8 (kb): |
1.3 |
|
Segment no. 9 (kb): |
1.2 |
|
Segment no. 10 (kb): |
1.2 |
|
Ten segment(s): |
23.5 (kb) total (calculated) |
|
G... |
||
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Barton ES et al (2001) Junction adhesion molecule is a receptor for reovirus. Cell 104:441–451
Chappell JD et al (2002) Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. EMBO J 21:1–11
Dryden KA et al (1993) Early steps in reovirus infection are associated with dramatic changes in supramolecular structure and protein conformation: analysis of virions and subviral particles by cryoelectron microscopy. J Cell Biol 122:1023–1041
Duncan R (1999) Extensive sequence divergence and phylogenetic relationships between the fusogenic and nonfusogenic orthoreoviruses: a species proposal. Virology 260:316–328
Fields BN (1971) Temperature-sensitive mutants of reovirus type 3: features of genetic recombination. Virology 46:142–148
Furuichi Y et al (1976) Mechanism of formation of reovirus mRNA 5'-terminal blocked and methylated sequence, m7G pppGmpC. J Biol Chem 251:5043–5053
Joklik WK, Roner MR (1996) Molecular recognition in the assembly of the segmented reovirus genome. Prog Nucleic Acid Res Mol Biol 53:249–281
Kobayashi T et al (2007) A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe 19:147–157
Kozak M, Shatkin AJ (1978) Identification of features in 5' terminal fragments from reovirus mRNA which are important for ribosome binding. Cell 13:201–212
Liemann S et al (2002) Structure of the reovirus membrane-penetration protein, mu1, in a complex with is protector protein, sigma3. Cell 108:283–295
Morrison LA, Fields BN (1991) Parallel mechanisms in neuropathogenesis of enteric virus infections. J Virol 65:2767–2772
Nibert ML et al (1991) Mechanisms of viral pathogenesis. Distinct forms of reoviruses and their roles during replication in cells and host. J Clin Invest 88:727–734
Norman KL, Lee PWK (2000) Reovirus as a novel oncolytic agent. J Clin Invest 105:1035–1038
Reinisch KM et al (2000) Structure of the reovirus core at 3.6 Å resolution. Nature 404:960–967
Roner MR, Joklik WK (2001) Reovirus reverse genetics: incorporation of the CAT gene into the reovirus genome. Proc Natl Acad Sci USA 98:8036–8041
Schiff LA et al (2006) Reoviruses. In: Knipe DM, Howley PM (eds) Fields virology, 5th edn. Lippincott Williams & Wilkins, Philadelphia
Sharpe AH, Fields BN (1985) Pathogenesis of viral infections. Basic concepts derived from the reovirus model. N Engl J Med 312:486–497
Shmulevitz M, Duncan R (2000) A new class of fusion-associated small transmembrane (FAST) proteins encoded by the non-enveloped fusogenic reoviruses. EMBO J 19:902–912
Skehel JJ, Joklik WK (1969) Studies on the in vitro transcription of reovirus RNA catalyzed by reovirus cores. Virology 39:822–831
Tao Y et al (2002) RNA synthesis in a cage – structural studies of reovirus polymerase lambda3. Cell 111:733–745
Tyler KL, Oldstone MBA (eds) (1998) Reoviruses I and Reoviruses II. Curr Top Microbiol Immunol, vols 238/I and 238/II
Tyler KL et al (1986) Distinct pathways of viral spread in the host determined by reovirus S1 gene segment. Science 233:770–774
Weiner HL et al (1980) Absolute linkage of virulence and central nervous system cell tropism of reoviruses to viral hemagglutinin. J Infect Dis 141:609–616
Wolf JL et al (1981) Intestinal M cells: a pathway for entry of reovirus into the host. Science 212:471–472
Zhang X et al (2003) Reovirus polymerase lambda3 localized by cryo-electron microscopy of virions at a resolution of 7.6 Å. Nat Struct Biol 10:1011–1018
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this entry
Cite this entry
Nibert, M.L., Duncan, R. (2011). Orthoreovirus. In: Tidona, C., Darai, G. (eds) The Springer Index of Viruses. Springer, New York, NY. https://doi.org/10.1007/978-0-387-95919-1_264
Download citation
DOI: https://doi.org/10.1007/978-0-387-95919-1_264
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-95918-4
Online ISBN: 978-0-387-95919-1
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences