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Mucous Membrane Pemphigoid

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Encyclopedia of Medical Immunology

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Synonym

Cicatricial pemphigoid

Definition

Mucous membrane pemphigoid (MMP), previously known as “cicatricial pemphigoid,” (Chan et al. 2002) is a chronic, autoimmune, subepithelial blistering disorder characterized by involvement of predominantly mucosal surfaces and a tendency for scarring.

HLA type DQB1*0301(DQ7) is common amongst patients with both MMP and classic bullous pemphigoid.

Clinical

A chronic and progressive disease, MMP may be associated with substantive morbidity due to the tendency for scarring and fibrosis. When present on the conjunctivae, these effects may lead to blindness.

The histopathologic presentation of MMP is similar to that observed in classic bullous pemphigoid but with fewer eosinophils and more plasma cells being present in the lymphohistiocytic infiltrate that surrounds the subepidermal blisters. Mast cells and other mononuclear leukocytes are also found. Later stages also show granulation tissue in the submucosa and the characteristic fibrosis in the...

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References

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Author information

Authors and Affiliations

  1. The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 240 East 38th Street, 11th Floor Administration, New York, NY, 10016, USA

    Bryan D. Sofen & Nicholas A. Soter

Authors
  1. Bryan D. Sofen
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  2. Nicholas A. Soter
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Corresponding author

Correspondence to Bryan D. Sofen .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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© 2014 Springer Science+Business Media New York

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Sofen, B.D., Soter, N.A. (2014). Mucous Membrane Pemphigoid. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_254

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_254

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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