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Transcoelomic Metastasis

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  • First Online:
Encyclopedia of Cancer

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Synonyms

Peritoneal metastasis/dissemination; Transabdominal metastasis/dissemination

Definition

Dissemination or spread of malignant tumor throughout the peritoneal (abdominal and pelvic) cavity.

Characteristics

Transcoelomic (meaning “across the peritoneal cavity”) metastasis refers to the dissemination of malignant tumors throughout the surfaces and organs of the abdominal and pelvic cavity covered by peritoneum. Transcoelomic metastasis can occur as a result of invasion into the peritoneal cavity by (1) a primary cancer arising from within the abdominal/pelvic cavity, e.g., ovarian cancer; (2) as a manifestation of systemic metastasis following haematogenous or lymphatic invasion by a primary cancer, e.g., advanced breast cancer; or (3) following intraperitoneal seeding during surgical manipulation, e.g., during surgical resection of a colorectal tumor.

The incidence of transcoelomic metastasis is higher with tumors that arise from the peritoneal cavity, e.g., ovarian (up to 70% of...

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References

  1. Fidler IJ (2002) Critical determinants of metastasis. Semin Cancer Biol 12(2):89–96

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  2. Tan DS, Agarwal R, Kaye SB (2006) Mechanisms of transcoelomic metastasis in ovarian cancer. Lancet Oncol 7(11):925–934

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  3. Becker G, Galandi D, Blum HE (2006) Malignant ascites: systematic review and guideline for treatment. Eur J Cancer 42(5):589–597

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  4. Koppe MJ, Boerman OC, Oyen WJ et al (2006) Peritoneal carcinomatosis of colorectal origin: incidence and current treatment strategies. Ann Surg 243(2):212–222

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Author information

Authors and Affiliations

  1. Section of Medicine, Institute of Cancer Research, The Royal Marsden Hospital, London, UK

    David S. P. Tan

  2. Drug Development Unit, Institute of Cancer Research, The Royal Marsden Hospital, Downs Road, SM2 5PT, Sutton, UK

    Stanley B. Kaye

Authors
  1. David S. P. Tan
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  2. Stanley B. Kaye
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Corresponding author

Correspondence to David S. P. Tan .

Editor information

Editors and Affiliations

  1. University Professor of Genetics, German Cancer Research Center - DKFZ, Heidelberg, Germany

    Manfred Schwab

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© 2011 Springer-Verlag Berlin Heidelberg

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Tan, D.S.P., Kaye, S.B. (2011). Transcoelomic Metastasis. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_5897

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