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Vascularization for Tissue Engineering and Regenerative Medicine

  • Living reference work
  • © 2020
  • Latest edition

Overview

Editors:
  1. Wolfgang Holnthoner

    1. AUVA Research Center, Ludwig Boltzmann Inst. Exp. a. Clinical AUVA Research Center, Wien, Vatican City State

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  2. Andrea Banfi

    1. Department of Biomedicine, University Hospital Basel Department of Biomedicine, Basel, Switzerland

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  3. James Kirkpatrick

    1. Institute for Pathology, Johannes Gutenberg University Institute for Pathology, Mainz, Germany

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  4. Heinz Redl

    1. LBI für experimentelle und klinisch, Wien, Austria

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  • Provides cutting-edge research in this discipline
  • Includes contributions from the TERMIS community
  • Addresses both clinical practitioners and researchers in academia
  • Written by international experts in the field

Part of the book series: Reference Series in Biomedical Engineering (RSBE)

Part of the book sub series: Tissue Engineering and Regeneration (TIENRE)

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Table of contents (18 entries)

  1. Angiogenesis: Basics of Vascular Biology

    • Victor W. M. van Hinsbergh

  2. Approaches for Generation of Lymphatic Vessels

    • Sabrina Rohringer, Mira Schaupper, Wolfgang Holnthoner

  3. Biomimetic Models of the Microcirculation for Scientific Discovery and Therapeutic Testing

    • Robert M. Dolan, Jessica Motherwell, Nicholas Hodges, Ariana D. Suarez-Martinez, Peter McFetridge, Cheryl Gomillion et al.

  4. Cell Sorting, Culture, Preconditioning, and Modulation/Cell Aggregates: Sheets

    • Botao Gao, Tatsuya Shimizu, Teruo Okano

  5. Co-Culture Systems for Vasculogenesis

    • Luba Perry, Shahar Ben-Shaul, Shira Landau, Shulamit Levenberg

  6. From Autologous Flaps to Engineered Vascularized Grafts for Bone Regeneration

    • Alexander Haumer, Tarek Ismail, Alexander Lunger, Rik Osinga, Arnaud Scherberich, Dirk Johannes Schaefer et al.

  7. From Secondary Intent to Accelerated Regenerative Healing: Emergence of the Bio-intelligent Scaffold Vasculogenic Strategy for Skin Reconstruction

    • J. F. Dye

  8. In Vitro and In Vivo Approaches for Pre-vascularization of 3-Dimensional Engineered Tissues

    • Geraldine M. Mitchell, Wayne A. Morrison

  9. Mechanical Regulation of Microvascular Growth and Remodeling

    • Laxminarayanan Krishnan, Steven A. LaBelle, Marissa A. Ruehle, Jeffrey A. Weiss, James B. Hoying, Robert E. Guldberg

  10. Microsurgical Approaches for In Vivo Prevascularization

    • Christoph Koepple, Ulrich Kneser, Volker J. Schmidt

  11. Microvascular Networks and Models, In vitro Formation

    • Ulrich Blache, Julien Guerrero, Sinan Güven, Agnes Silvia Klar, Arnaud Scherberich

  12. Past and Future Prevascularization Strategies with Clinical Relevance: Leading to a Dual Approach

    • Karl H. Schneider, Sabrina Rohringer, Wolfgang Holnthoner, Severin Mühleder, Heinz Redl

  13. Perfusion Bioreactors for Prevascularization Strategies in Cardiac Tissue Engineering

    • Ingra Mannhardt, Anna Marsano, Andreas Teuschl

  14. Probing Vasculature by In Vivo Phage Display for Target Organ-Specific Delivery in Regenerative Medicine

    • Toini Pemmari, Tiia Koho, Tero A. H. Järvinen

  15. Stimulation by Light

    • S. Chaudary, S. Rieger, H. Redl, P. Dungel

  16. Targeting the Cellular “Oxygen Sensors”: Hypoxia Pre-Conditioning and Stabilization of Hypoxia-Inducible Factors

    • Hermann Agis

  17. Therapeutic Angiogenesis in Regenerative Medicine

    • Veronica Sacchi, Rainer Mittermayr, Martin Ehrbar

  18. Therapeutic Angiogenesis: Translational and Clinical Experience

    • Henna Korpela, Jaakko Lampela, Jussi Nurro, Juho Pajula, Seppo Ylä-Herttuala
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About this book

This reference work presents the basic principles of angiogenesis induction, including the roles of signaling factors such as hypoxia-inducible factors, biophysical stimulation and angiogenic cells. The book also covers lymphogenesis induction. Both the established fundamentals in the field as well as new trends in the vascularization of engineered tissues are discussed. These include pre-vascularization strategies using preparation of channeled scaffolds and preparation of decellularized blood vessel trees, approaches to inducing formation of microvasculature and approaches to inducing the growth of vascular networks. The authors expand on these concepts with current studies of dual-level approaches to engineer vascularized tissue composites. The book concludes with a discussion of current clinical approaches and the use of vascular grafts in the context of providing clinical practice with new tissue engineering strategies.

Editors and Affiliations

  • AUVA Research Center, Ludwig Boltzmann Inst. Exp. a. Clinical AUVA Research Center, Wien, Vatican City State

    Wolfgang Holnthoner

  • Department of Biomedicine, University Hospital Basel Department of Biomedicine, Basel, Switzerland

    Andrea Banfi

  • Institute for Pathology, Johannes Gutenberg University Institute for Pathology, Mainz, Germany

    James Kirkpatrick

  • LBI für experimentelle und klinisch, Wien, Austria

    Heinz Redl

About the editors

Prof. Heinz Redl has served as Director of the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (LBI Trauma), part of the AUVA Research Center, since 1998 and is the founder of Trauma Care Consult, a company intended to promote collaboration with industry. His goals are to improve the diagnostic and therapeutic options available to trauma patients, and to establish new national and international networks – as can be seen in the 2006 launch of the Austrian Cluster for Tissue Regeneration and subsequent creation of the European Institute of Excellence for Tissue Engineering and Regenerative Medicine (Expertissue), which he co-founded.

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