Abstract
Wound healing in adult mammals proceeds by a series of overlapping highly coordinated events. Dermal wound repair commences with the arrest of hemorrhage followed by an inflammatory response, re-epithelialization of the wound, and formation of granulation tissue within the wound space, culminating in the production of a scar (1,2). In order to study the processes involved in the repair of wounded tissue, we have developed a rodent model utilizing full thickness incisional and excisional dermal wounds, which allow for macroscopic observations and also provide tissue for the histological and immunocytochemical analysis of acute wounds and scarring.
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Acknowledgments
The authors would like to thank Miss Hayley Willis for her invaluable help in preparing the figures.
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Birch, M., Tomlinson, A., Ferguson, M.W.J. (2005). Animal Models for Adult Dermal Wound Healing. In: Varga, J., Brenner, D.A., Phan, S.H. (eds) Fibrosis Research. Methods in Molecular Medicine, vol 117. Humana Press. https://doi.org/10.1385/1-59259-940-0:223
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DOI: https://doi.org/10.1385/1-59259-940-0:223
Publisher Name: Humana Press
Print ISBN: 978-1-58829-479-1
Online ISBN: 978-1-59259-940-0
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