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Generation of Transgenic Mice for Studies of Ocular Development and Disease

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Vision Research Protocols

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 47))

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Abstract

Over the past decade, there has been spectacular growth in our understanding of the molecular genetics of eye development and ocular disease. Although this is primarily caused by developments in recombinant DNA technology, it is also caused in large part by advances in, and the spread of, transgenic mouse technology. Whereas 10 years ago few laboratories had the equipment and skill to generate transgenic mice, now most investigators have access to a transgenic core facility. Transgenic mouse studies have fueled our understanding of ocular development, have delineated regulatory elements involved in gene expression in cells of the eye, and have unraveled pathogenic mechanisms involved in eye disease.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA

    Abha R. Gupta, Nadine S. Dejneka & Albert M. Maguire

  2. Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA

    Jean Bennett

Authors
  1. Abha R. Gupta
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  2. Nadine S. Dejneka
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  3. Albert M. Maguire
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  4. Jean Bennett
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Editors and Affiliations

  1. Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Nedlands, Perth

    P. Elizabeth Rakoczy

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© 2001 Humana Press Inc.

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Gupta, A.R., Dejneka, N.S., Maguire, A.M., Bennett, J. (2001). Generation of Transgenic Mice for Studies of Ocular Development and Disease. In: Rakoczy, P.E. (eds) Vision Research Protocols. Methods in Molecular Medicine™, vol 47. Humana Press. https://doi.org/10.1385/1-59259-085-3:191

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  • DOI: https://doi.org/10.1385/1-59259-085-3:191

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-837-0

  • Online ISBN: 978-1-59259-085-8

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