Abstract
Numerous proteins contain domains that are enriched in glutamine and asparagine residues, and aggregation of some of these proteins has been linked to both prion formation in yeast and a number of human diseases. Unfortunately, predicting whether a given glutamine/asparagine-rich protein will aggregate has proven difficult. Here we describe a recently developed algorithm designed to predict the aggregation propensity of glutamine/asparagine-rich proteins. We discuss the basis for the algorithm, its limitations, and usage of recently developed online and downloadable versions of the algorithm.
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Acknowledgements
This work was supported by a National Science Foundation grant (MCB-1023771) to E.D.R.
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Ross, E.D., MacLea, K.S., Anderson, C., Ben-Hur, A. (2013). A Bioinformatics Method for Identifying Q/N-Rich Prion-Like Domains in Proteins. In: Hatters, D., Hannan, A. (eds) Tandem Repeats in Genes, Proteins, and Disease. Methods in Molecular Biology, vol 1017. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-438-8_16
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DOI: https://doi.org/10.1007/978-1-62703-438-8_16
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