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Neuroimmune Mechanisms of Depression in Heart Failure

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Psychoneuroimmunology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 934))

Abstract

Heart failure (HF) is a major and costly public health concern, and its prognosis is grim—with high hospitalization and mortality rates. It is well documented that HF patients experience disproportionately high rates of depression and that depressed HF patients have worse clinical outcomes than their non-depressed counterparts. The purpose of this chapter is to introduce the reader to the study of depression in HF, and how psychoneuroimmunologic principals have been applied to further elucidate the mechanisms (i.e., neurohormonal and cytokine activation) linking these co-morbid disorders.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, University of California at San Diego, San Diego, CA, USA

    Jessica A. Jiménez

  2. Department of Psychiatry, University of California San Diego, San Diego, CA, USA

    Paul J. Mills

Authors
  1. Jessica A. Jiménez
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  2. Paul J. Mills
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Corresponding author

Correspondence to Paul J. Mills .

Editor information

Editors and Affiliations

  1. PharmTao, Lafayette St 4601, Santa Clara, 95056, California, USA

    Qing Yan

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Jiménez, J.A., Mills, P.J. (2012). Neuroimmune Mechanisms of Depression in Heart Failure. In: Yan, Q. (eds) Psychoneuroimmunology. Methods in Molecular Biology, vol 934. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-071-7_9

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  • DOI: https://doi.org/10.1007/978-1-62703-071-7_9

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-070-0

  • Online ISBN: 978-1-62703-071-7

  • eBook Packages: Springer Protocols

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