Abstract
Phage infections in bacterial bioprocesses constitute one of the most devastating threats to the productivity of the biotechnology facilities. There are several factors, which can decide if an infection would occur, and if it would turn into an outbreak and heavy contamination of the production facility. This issue is discussed on the basis of literature survey and experience of Phage Consultants.
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References
Whitman, W.B., Coleman, D.C., Wiebe, W.J. (1998) Prokaryotes: the unseen majority. Proc. Natl. Acad. Sci. USA. 95, 6578–6583.
Primrose, S. B. (1990). Controlling bacteriophage infections in industrial bioprocesses, p. 1–10. In J. Reiser (ed.), Applied molecular genetics. Springer-Verlag, Berlin.
Bogosian, G. (2006) Control of bacteriophage in commercial microbiology and fermentation facilities. In Calendar R, Abedon ST (Ed.), “The Bacteriophages. 2nd ed”., Oxford University Press, New York.
Wietzorrek, A., Schwarz, H., Herrmann, C., Braun, V. (2006) The genome of the novel phage Rtp, with a rosette-like tail tip, is homologous to the genome of phage T1 . J. Bacteriol. 188, 1419–1436.
Bruttin, A., Brüssow, H. (1996) Site-specific spontaneous deletions in three genome regions of a temperate Streptococcus thermophilus phage. Virology 219, 96–104.
Rotman, E., Amado, L., Kuzminov, A. (2010) Unauthorized horizontal spread in the laboratory environment: the tactics of Lula, a temperate lambdoid bacteriophage of Escherichia coli. PLoS One 5:e11106.
Los, M., Kuzio, J., McConnell, M.R., Kropinski, A.M., Wegrzyn, G, Christie, G.E., (2010) Lysogenic Conversion in Bacteria of Importance to the food Industry in “Bacteriophages In the Control of Food- and Waterborne Pathogens”. ASM press, Washington, DC, USA. 157–198.
Los, M., Czyz, A., Sell, E., Wegrzyn, A., Neubauer, P., Wegrzyn, G. (2004) Bacteriophage contamination: is there a simple method to reduce its deleterious effects in laboratory cultures and biotechnological factories? J. Appl. Genet. 45, 111–120.
Los, M. (2010). Contamination concerns. European Biopharmaceutical Review, 51, 78–80.
Ogata, S. 1980. Bacteriophage contamination in industrial processes. Biotechnol. Bioeng. 22(Suppl. 1), 177–193.
Wu,W.-W., Yoshinaga, K., Kanda, K., Kato, F., Murata, A., (1991). Phage S2, another new phage for serine-producing Eschericha coli. Bull. Fac. Agr. Saga Univ. 71, 123–132.
Wu, W.-W., Tanaka, K., Kato, F., Murata, A., (1991) Phage S1, new phage for Eschericha coli. Bull. Fac. Agr. Saga Univ. 71, 91–100.
Teuber, M., Andresen, A., Sievers, M. (1987) Bacteriophage problems in vinegar fermentations. Biotechnol. Lett. 9, 37–38.
Koptides, M., Barak, I., Sisova, M., Baloghova, E., Ugorackova, J., Timko, J. (1992) Characterization of bacteriophage BFK20 from Brevibacterium flavum. J. Gen. Microbiol. 138, 1387–1391.
Jones, D.T., Shirley, M., Wu, X., Keis, S. (2000) Acetone Butanol (AB) Fermentation Process. J. Mol. Microbiol. Biotechnol. 2, 21–26.
Maeda, A., Ishii, K., Tanaka, M., Mikami, Y., Arai, T., (1986) KMl, a Bacteriophage of Clostvidium butyvicum J. Gen. Microbiol. 132, 2271–2275.
Bartholomew, W. H., Engstrom, D. E.,Goodman, S. S., O’Toole, A. L., Shelton, J. L.,Tannen L. P. (1974) Reduction of contamination in an industrial fermentation plant. Biotechnol Bioeng. 16, 1005–1013.
Josephsen, J., Petersen, A., Neve, H., Waagner, E. (1999) Development of lytic Lactococcus lactis bacteriophages in a Cheddar cheese plant. Int. J. Food Microbiol. 50, 163–171.
Seregant, K., Yeo, R.G. (1966) The production of bacteriophage m2. Biotechnol. Bioeng. 8, 195–215.
Los, M., Wegrzyn, G., Neubauer, P. (2003) A role for bacteriophage T4 rI gene function in the control of phage development during pseudolysogeny and in slowly growing host cells. Res. Microbiol. 154, 547–552.
Los, M., Golec, P., Los, J.M., Weglewska-Jurkiewicz, A., Czyz, A., Wegrzyn, A., Wegrzyn, G., Neubauer, P. (2007) Effective inhibition of lytic development of bacteriophages lambda, P1 and T4 by starvation of their host, Escherichia coli. BMC Biotechnol. 7:13.
Adams, M.H. (1959). Bacteriophages. Interscience Publishers, New York, pp. 450–456.
Los, J.M., Golec, P., Wegrzyn. G., Wegrzyn, A., Los. M. (2008). Simple method for plating Escherichia coli bacteriophages forming very small plaques or no plaques under standard conditions. Appl. Environ. Microbiol. 74, 5113–5120.
Lilehaug, D. (1997). An improved plaque assay for poor plaque-producing temperate lactococcal bacteriophages. J. Appl. Microbiol. 83, 85–90.
Los, M., Los, J.M., Blohm, L., Spillner, E., Grunwald, T., Albers, J., Hintsche R., Wegrzyn, G. (2005). Rapid detection of viruses using electrical biochips and anti-virion sera. Lett. Appl. Microbiol. 40, 479–85.
Los,M., Los, J.M., Wegrzyn, G. (2008). Rapid identification of Shiga toxin-producing Escherichia coli (STEC) using electric biochips. Diagn. Mol. Pathol. 17, 179–184.
Chen, Y., Golding, I., Sawai, S., Guo, L., Cox, E.C. (2005) Population Fitness and the Regulation of Escherichia coli Genes by Bacterial Viruses. PLoS Biol. 3, 1276–1282.
Edlin, G., Lin, L., Bitner, R., (1977) Reproductive fitness of P1, P2, and Mu lysogens of Escherichia coli. J Virol. 21, 560–564.
Lin, L., Bitner, R. Edlin, G. (1977), Increased Reproductive Fitness of Escherichia coli Lambda Lysogens J Virol. 21, 554–559.
Pollard, E., Reaume, M. (1951) Thermal inactivation of bacterial viruses. Arch. Biochem. 32, 278–287.
Acknowledgments
This work was partially supported by the European Union within European Regional Development Fund, through grant Innovative Economy (POIG.01.01.02-00-008/08).
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Los, M. (2012). Minimization and Prevention of Phage Infections in Bioprocesses. In: Cheng, Q. (eds) Microbial Metabolic Engineering. Methods in Molecular Biology, vol 834. Springer, New York, NY. https://doi.org/10.1007/978-1-61779-483-4_19
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DOI: https://doi.org/10.1007/978-1-61779-483-4_19
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