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General Consideration on Sialic Acid Chemistry

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Carbohydrate Microarrays

Part of the book series: Methods in Molecular Biology ((MIMB,volume 808))

Abstract

Sialic acids, also known as neuraminic acids, are a family of negatively charged α-keto acids with a nine-carbon backbone. These unique sugars have been found at the termini of many glycan chains of vertebrate cell surface, which play pivotal roles in mediating or modulating a variety of physiological and pathological processes. This brief review covers general approaches for synthesizing sialic acid containing structures. Recently developed synthetic methods along with structural diversities and biological functions of sialic acid are discussed.

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Acknowledgments

We are grateful for financial supports from Shandong University (to H.C.), the National Science Foundation of China (No. 20902087 to H.C.), the Natural Science Foundation of Shandong Province (SDNSF, No. ZR2010BM018 to H.C.), the University of California-Davis (to X.C.), the National Institutes of Health (R01GM076360 and U01CA128442 to X.C.), the National Science Foundation (CAREER Award 0548235 to X.C.), Alfred P. Sloan Foundation (to X.C.), and the Camille & Henry Dreyfus Foundation (to X.C.). X.C. is an Alfred P. Sloan Research Fellow, a Camille Dreyfus Teacher-Scholar, and a UC-Davis Chancellor’s Fellow.

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  1. National Glycoengineering Research Center, Shandong University, Jinan, Shandong, People’s Republic of China

    Hongzhi Cao

  2. Department of Chemistry, University of California, Davis, CA, USA

    Xi Chen

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  1. Hongzhi Cao
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  2. Xi Chen
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Correspondence to Hongzhi Cao or Xi Chen .

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  1. CNRS UMR 5270, Inst. Nanotechnologies de Lyon, Université Lyon 1, av. Guy de Collongue 36, Ecully, 69134, France

    Yann Chevolot

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Cao, H., Chen, X. (2012). General Consideration on Sialic Acid Chemistry. In: Chevolot, Y. (eds) Carbohydrate Microarrays. Methods in Molecular Biology, vol 808. Humana Press. https://doi.org/10.1007/978-1-61779-373-8_3

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  • DOI: https://doi.org/10.1007/978-1-61779-373-8_3

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