Abstract
The synthesis of molecular conjugates through chemoselective ligations represents a very convenient strategy to prepare complex macromolecules with diverse functional elements. Herein, we describe chemical methods based on the preparation of chemoselectively addressable peptides allowing successive oxime ligations and/or alkyne–azide cycloaddition (“click”) reactions of various biomolecules. This modular synthetic approach can be applied to a broad range of purposes.
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Acknowledgements
We thank the Université Joseph Fourier (UJF-Grenoble), the Centre National de la Recherche Scientifique (CNRS), and the NanoBio program (Grenoble) for providing support for this work.
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Galibert, M., Renaudet, O., Boturyn, D., Dumy, P. (2011). Preparation of Peptide and Other Biomolecular Conjugates Through Chemoselective Ligations. In: Mark, S. (eds) Bioconjugation Protocols. Methods in Molecular Biology, vol 751. Humana Press. https://doi.org/10.1007/978-1-61779-151-2_6
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DOI: https://doi.org/10.1007/978-1-61779-151-2_6
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