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Brain Redox Imaging

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Magnetic Resonance Neuroimaging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 711))

Abstract

Nitroxyl contrast agents (nitroxyl radicals, also known as nitroxide) are paramagnetic species, which can react with reactive oxygen species (ROS) to lose paramagnetism to be diamagnetic species. The paramagnetic nitroxyl radical forms can be detected by using electron paramagnetic resonance imaging (EPRI), Overhauser MRI (OMRI), or MRI. The time course of in vivo image intensity induced by paramagnetic redox-sensitive contrast agent can give tissue redox information, which is the so-called redox imaging technique. The redox imaging technique employing a blood–brain barrier permeable nitroxyl contrast agent can be applied to analyze the pathophysiological functions in the brain. A brief theory of redox imaging techniques is described, and applications of redox imaging techniques to brain are introduced.

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Authors and Affiliations

  1. Radiation Modifier Research Team, Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Chiba, Japan

    Ken-ichiro Matsumoto & Kazunori Anzai

  2. Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan

    Fuminori Hyodo & Hideo Utsumi

  3. Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, MD, USA

    James B. Mitchell

  4. Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Center for Cancer Research, Bethesda, MD, USA

    Murali C. Krishna

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  1. Ken-ichiro Matsumoto
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  2. Fuminori Hyodo
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  3. Kazunori Anzai
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  4. Hideo Utsumi
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  5. James B. Mitchell
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  6. Murali C. Krishna
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Editors and Affiliations

  1. Institute of Psychiatry, Department of Neuroscience, King's College London, Coldharbour Lane 125, London, SE5 9NU, United Kingdom

    Michel Modo

  2. Institute of Cell Engineering, Dept Radiology & Radiological Sciences, Johns Hopkins Univ. Sch. of Med., Rutland Ave. 720, Baltimore, 21205, Maryland, USA

    Jeff W.M. Bulte

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Matsumoto, Ki., Hyodo, F., Anzai, K., Utsumi, H., Mitchell, J.B., Krishna, M.C. (2011). Brain Redox Imaging. In: Modo, M., Bulte, J. (eds) Magnetic Resonance Neuroimaging. Methods in Molecular Biology, vol 711. Humana Press. https://doi.org/10.1007/978-1-61737-992-5_20

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  • DOI: https://doi.org/10.1007/978-1-61737-992-5_20

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