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Three-Dimensional Structures of DNA-Bound Transcriptional Regulators

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Computational Biology of Transcription Factor Binding

Part of the book series: Methods in Molecular Biology ((MIMB,volume 674))

Abstract

Our understanding of the detailed mechanisms of specific promoter/enhancer DNA-binding site recognition by transcriptional regulatory factors is primarily based on three-dimensional structural studies using the methods of X-ray crystallography and NMR. Vast amount of accumulated experimental data have revealed the basic principles of protein–DNA complex formation paving the way for better modeling and prediction of DNA-binding properties of transcription factors. In this review, our intent is to provide a general overview of the three-dimensional structures of DNA-bound transcriptional regulators starting from the basic principles of specific DNA recognition and ending with high-order multiprotein–DNA complexes.

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Authors and Affiliations

  1. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA

    Tripti Shrivastava & Tahir H. Tahirov

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  1. Tripti Shrivastava
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  2. Tahir H. Tahirov
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Correspondence to Tahir H. Tahirov .

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Editors and Affiliations

  1. , Department of Statistics, University of Nebraska-Lincoln, Vine Street 1901, Lincoln, 68588-0665, Nebraska, USA

    Istvan Ladunga

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Shrivastava, T., Tahirov, T.H. (2010). Three-Dimensional Structures of DNA-Bound Transcriptional Regulators. In: Ladunga, I. (eds) Computational Biology of Transcription Factor Binding. Methods in Molecular Biology, vol 674. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-854-6_4

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  • DOI: https://doi.org/10.1007/978-1-60761-854-6_4

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-853-9

  • Online ISBN: 978-1-60761-854-6

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