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Systems Biology and Theranostic Approach to Drug Discovery and Development to Treat Traumatic Brain Injury

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Systems Biology in Drug Discovery and Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 662))

Abstract

Traumatic brain injury is a significant disease affecting 1.4 to 2 million patients every year in the USA. Currently, there are no FDA-approved therapeutic remedies to treat TBI despite the fact that there have been over 200 clinical drug trials, all which have failed. These drugs used the traditional single drug-to-target approach of drug discovery and development. An alternative based upon the advances in genomics, proteomics, bioinformatic tools, and systems biology software has enabled us to use a Systems Biology-based approach to drug discovery and development for TBI. It focuses on disease-relevant converging pathways as potential therapeutic intervention points and is accompanied by downstream biomarkers that allow for the tracking of drug targeting and appears to correlate with disease mitigation. When realized, one is able to envision that a companion diagnostic will be codeveloped along the therapeutic compound. This “theranostic” approach is perfectly positioned to align with the emerging trend toward “personalized medicine”.

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, McKnight Brain Institute of the University of Florida, Gainesville, FL, USA

    Firas Kobeissy & Kevin K. W. Wang

  2. Center of Innovative Research, Banyan Biomarkers, Inc., Alachua, FL, USA

    Zhiqun Zhang & Kevin K. W. Wang

  3. Banyan Biomarkers, Inc., Alachua, FL, USA

    Stephen F. Larner & Ronald L. Hayes

Authors
  1. Zhiqun Zhang
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  2. Stephen F. Larner
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  3. Firas Kobeissy
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  4. Ronald L. Hayes
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  5. Kevin K. W. Wang
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Corresponding author

Correspondence to Kevin K. W. Wang .

Editor information

Editors and Affiliations

  1. PharmTao, Santa Clara, California, USA

    Qing Yan

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© 2010 Springer Science+Business Media, LLC

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Zhang, Z., Larner, S.F., Kobeissy, F., Hayes, R.L., Wang, K.K.W. (2010). Systems Biology and Theranostic Approach to Drug Discovery and Development to Treat Traumatic Brain Injury. In: Yan, Q. (eds) Systems Biology in Drug Discovery and Development. Methods in Molecular Biology, vol 662. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-800-3_16

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  • DOI: https://doi.org/10.1007/978-1-60761-800-3_16

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-799-0

  • Online ISBN: 978-1-60761-800-3

  • eBook Packages: Springer Protocols

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