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What Is Cancer Nanotechnology?

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Cancer Nanotechnology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 624))

Abstract

Cancer nanotechnology has the potential to dramatically improve current approaches to cancer detection, diagnosis, imaging, and therapy while reducing toxicity associated with traditional cancer therapy (1, 2). In this overview, we will define cancer nanotechnology, consider issues related to application of nanotechnology for cancer imaging and therapy, and broadly consider implications for continued development in nanotechnology for the future of clinical cancer care. These considerations will place in perspective the methodological approaches in cancer nanotechnology and subject reviews outlined in this volume.

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References

  1. Cuenca, A. G., Jiang, H., Hochwald, S. N., Delano, M., Cance, W. G., and Grobmyer, S. R. (2006) Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer 107(3), 459–466.

    Article  CAS  PubMed  Google Scholar 

  2. Alexis, F., Rhee, J. W., Richie, J. P., Radovic-Moreno, A. F., Langer, R., and Farokhzad, O. C. (2008) New frontiers in nanotechnology for cancer treatment. Urol Oncol 26(1), 74–85.

    CAS  PubMed  Google Scholar 

  3. Hartman, K. B., Wilson, L. J., and Rosenblum, M. G. (2008) Detecting and treating cancer with nanotechnology. Mol Diagn Ther 12(1), 1–14.

    CAS  PubMed  Google Scholar 

  4. De Jong, W. H. and Borm, P. J. (2008) Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine 3(2), 133–149.

    Article  PubMed  Google Scholar 

  5. Duncan, R., Kreyling, W. G., Biosseau, P., Cannistraro, S., Coatrieux, J., Conde, J. P., Hennick, W., Oberleithner, H., and Rivas, J. (2005) ESF scientific forward look on nanomedicine. In European Science Foundation Policy Briefing. 1–6.

    Google Scholar 

  6. Cho, K., Wang, X., Nie, S., Chen, Z. G., and Shin, D. M. (2008) Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 14(5), 1310–1316.

    Article  CAS  PubMed  Google Scholar 

  7. Heath, J. R. and Davis, M. E. (2008) Nanotechnology and cancer. Annu Rev Med 59, 251–265.

    Article  CAS  PubMed  Google Scholar 

  8. Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., and Langer, R. (2007) Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2(12), 751–760.

    Article  CAS  PubMed  Google Scholar 

  9. Maurer-Jones, M. A., Bantz, K. C., Love, S. A., Marquis, B. J., and Haynes, C. L. (2009) Toxicity of therapeutic nanoparticles. Nanomed 4(2), 219–241.

    Article  CAS  Google Scholar 

  10. Powers, K. W., Brown, S. C., Krishna, V. B., Wasdo, S. C., Moudgil, B. M., and Roberts, S. M. (2006) Research strategies for safety evaluation of nanomaterials. Part VI. Characterization of nanoscale particles for toxicological evaluation. Toxicol Sci 90(2), 296–303.

    Article  CAS  PubMed  Google Scholar 

  11. Dobrovolskaia, M. A. and McNeil, S. E. (2007) Immunological properties of engineered nanomaterials. Nat Nanotechnol 2(8), 469–478.

    Article  CAS  PubMed  Google Scholar 

  12. Marquis, B. J., Love, S. A., Braun, K. L., and Haynes, C. L. (2009) Analytical methods to assess nanoparticle toxicity. Analyst 134(3), 425–439.

    Article  CAS  PubMed  Google Scholar 

  13. Lammers, T., Hennink, W. E., and Storm, G. (2008) Tumour-targeted nanomedicines: principles and practice. Br J Cancer 99(3), 392–397.

    Article  CAS  PubMed  Google Scholar 

  14. Maeda, H. and Matsumura, Y. (1989) Tumoritropic and lymphotropic principles of macromolecular drugs. Crit Rev Ther Drug Carrier Syst 6(3), 193–210.

    CAS  PubMed  Google Scholar 

  15. Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., and Jain, R. K. (1995) Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Res 55(17), 3752–3756.

    CAS  PubMed  Google Scholar 

  16. Kong, G., Braun, R. D., and Dewhirst, M. W. (2000) Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. Cancer Res 60(16), 4440–4445.

    CAS  PubMed  Google Scholar 

  17. Allen, T. M. (2002) Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2(10), 750–763.

    Article  CAS  PubMed  Google Scholar 

  18. Black, K. C., Kirkpatrick, N. D., Troutman, T. S., Xu, L., Vagner, J., Gillies, R. J., Barton, J. K., Utzinger, U., and Romanowski, M. (2008) Gold nanorods targeted to delta opioid receptor: plasmon-resonant contrast and photothermal agents. Mol Imaging 7(1), 50–57.

    CAS  PubMed  Google Scholar 

  19. Cho, K., Wang, X., Nie, S., Chen, Z., and Shin, D. M. (2008) Therapeutic nanoparticles for drug delivery in cancer. Clinical Cancer Research 14(5), 1310–1315.

    Article  CAS  PubMed  Google Scholar 

  20. Santra, S., Liesenfeld, B., Dutta, D., Chatel, D., Batich, C. D., Tan, W., Moudgil, B. M., and Mericle, R. A. (2005) Folate conjugated fluorescent silica nanoparticles for labeling neoplastic cells. J Nanosci Nanotechnol 5(6), 899–904.

    Article  CAS  PubMed  Google Scholar 

  21. Sahoo, S. K., Ma, W., and Labhasetwar, V. (2004) Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer. Int J Cancer 112(2), 335–340.

    Article  CAS  PubMed  Google Scholar 

  22. Smith, B. R., Cheng, Z., De, A., Koh, A. L., Sinclair, R., and Gambhir, S. S. (2008) Real-Time Intravital Imaging of RGD-Quantum Dot Binding to Luminal Endothelium in Mouse Tumor Neovasculature. Nano Lett 8(9), 2599–2606.

    Article  CAS  PubMed  Google Scholar 

  23. Kirpotin, D. B., Drummond, D. C., Shao, Y., Shalaby, M. R., Hong, K., Nielsen, U. B., Marks, J. D., Benz, C. C., and Park, J. W. (2006) Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 66(13), 6732–6740.

    Article  CAS  PubMed  Google Scholar 

  24. Park, J. W., Benz, C. C., and Martin, F. J. (2004) Future directions of liposome- and immunoliposome-based cancer therapeutics. Semin Oncol 31(6 Suppl 13), 196–205.

    Article  CAS  PubMed  Google Scholar 

  25. Hood, E. (2004) Nanotechnology: looking as we leap. Environ Health Perspect 112(13), A740–A749.

    Article  PubMed  Google Scholar 

  26. Jabr-Milane, L. S., van Vlerken, L. E., Yadav, S., and Amiji, M. M. (2008) Multi-functional nanocarriers to overcome tumor drug resistance. Cancer Treat Rev 34(7), 592–602.

    Article  CAS  PubMed  Google Scholar 

  27. Sharma, P., Brown, S., Walter, G., Santra, S., and Moudgil, B. (2006) Nanoparticles for bioimaging. Adv Colloid Interface Sci 123–126, 471–485.

    Article  PubMed  Google Scholar 

  28. Jun, Y. W., Jang, J. T., and Cheon, J. (2007) Magnetic nanoparticle assisted molecular MR imaging. Adv Exp Med Biol 620, 85–106.

    Article  PubMed  Google Scholar 

  29. Will, O., Purkayastha, S., Chan, C., Athanasiou, T., Darzi, A. W., Gedroyc, W., and Tekkis, P. P. (2006) Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis. Lancet Oncol 7(1), 52–60.

    Article  PubMed  Google Scholar 

  30. Pope-Harman, A., Cheng, M. M., Robertson, F., Sakamoto, J., and Ferrari, M. (2007) Biomedical nanotechnology for cancer. Med Clin North Am 91(5), 899–927.

    Article  CAS  PubMed  Google Scholar 

  31. Sun, C., Lee, J. S., and Zhang, M. (2008) Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 60(11), 1252–1265.

    Article  CAS  PubMed  Google Scholar 

  32. Hoelen, C. G. A., de Mul, F. F. M., Pongers, R., and Dekker, A. (1998) Three-dimensional photoacoustic imaging of blood vessels in optical tissue. Opt Lett 23, 648–650.

    Article  CAS  PubMed  Google Scholar 

  33. Copland, J. A., Eghtedari, M., Popov, V. L., Kotov, N., Mamedova, N., Motamedi, M., and Oraevsky, A. A. (2004) Bioconjugated gold nanoparticles as a molecular based contrast agent: implications for imaging of deep tumors using optoacoustic tomography. Mol Imaging Biol 6(5), 341–349.

    Article  PubMed  Google Scholar 

  34. Yuan, Z. and Jiang, H. (2006) Quantitative photoacoustic tomography: recovery of optical absorption coefficient maps of heterogeneous media. Appl Phys Lett 88(231101), 231101–231103.

    Article  Google Scholar 

  35. Yang, X., Skrabalak, S. E., Li, Z. Y., Xia, Y., and Wang, L. V. (2007) Photoacoustic tomography of a rat cerebral cortex in vivo with au nanocages as an optical contrast agent. Nano Lett 7(12), 3798–3802.

    Article  CAS  PubMed  Google Scholar 

  36. De la Zerda, A., Zavaleta, C., Keren, S., Vaithilingam, S., Bodapati, S., Liu, Z., Levi, J., Smith, B. R., Ma, T. J., and Oralkan, O. et al. (2008) Carbon nanotubes as photoacoustic molecular imaging agents in living mice. Nat Nanotechnol 3(9), 557–562.

    Article  PubMed  Google Scholar 

  37. Sharma, P., Brown, S. C., Bengtsson, N., Zhang, Q., Walter, G. A., Grobmyer, S. R., Santa, S., Jiang, H., Scott, E., and Moudgil, B. (2008) Gold-speckled multimodal nanoparticles for noninvasive bioimaging. Chemistry of Materials 20(19), 6087–6094.

    Article  CAS  PubMed  Google Scholar 

  38. McCarthy, J. R., Kelly, K. A., Sun, E. Y., and Weissleder, R. (2007) Targeted delivery of multifunctional magnetic nanoparticles. Nanomed 2(2), 153–167.

    Article  CAS  Google Scholar 

  39. Jun, Y. W., Huh, Y. M., Choi, J. S., Lee, J. H., Song, H. T., Kim, S., Yoon, S., Kim, K. S., Shin, J. S., and Suh, J. S. et al. (2005) Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J Am Chem Soc 127(16), 5732–5733.

    Article  CAS  PubMed  Google Scholar 

  40. Moghimi, S. M., Hunter, A. C., and Murray, J. C. (2005) Nanomedicine: current status and future prospects. Faseb J 19(3), 311–330.

    Article  CAS  PubMed  Google Scholar 

  41. Portney, N. G. and Ozkan, M. (2006) Nano-oncology: drug delivery, imaging, and sensing. Anal Bioanal Chem 384(3), 620–630.

    Article  CAS  PubMed  Google Scholar 

  42. Sengupta, S., Eavarone, D., Capila, I., Zhao, G., Watson, N., Kiziltepe, T., and Sasisekharan, R. (2005) Temporal targeting of tumour cells and neovasculature with a nanoscale delivery system. Nature 436(7050), 568–572.

    Article  CAS  PubMed  Google Scholar 

  43. Hainfeld, J. F., Slatkin, D. N., and Smilowitz, H. M. (2004) The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol 49(18), N309–N315.

    Article  CAS  PubMed  Google Scholar 

  44. Chang, M. Y., Shiau, A. L., Chen, Y. H., Chang, C. J., Chen, H. H., and Wu, C. L. (2008) Increased apoptotic potential and dose-enhancing effect of gold nanoparticles in combination with single-dose clinical electron beams on tumor-bearing mice. Cancer Sci 99(7), 1479–1484.

    Article  CAS  PubMed  Google Scholar 

  45. Gannon, C. J., Patra, C. R., Bhattacharya, R., Mukherjee, P., and Curley, S. A. (2008) Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells. J Nanobiotechnol 6, 2.

    Article  Google Scholar 

  46. Cardinal, J., Klune, J. R., Chory, E., Jeyabalan, G., Kanzius, J. S., Nalesnik, M., and Geller, D. A. (2008) Noninvasive radiofrequency ablation of cancer targeted by gold nanoparticles. Surgery 144(2), 125–132.

    Article  PubMed  Google Scholar 

  47. Gannon, C. J., Cherukuri, P., Yakobson, B. I., Cognet, L., Kanzius, J. S., Kittrell, C., Weisman, R. B., Pasquali, M., Schmidt, H. K., and Smalley, R. E. et al. (2007) Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field. Cancer 110(12), 2654–2665.

    Article  CAS  PubMed  Google Scholar 

  48. Tassinari, O. W., Caiazzo, R. J., Jr., Ehrlich, J. R., and Liu, B. C. (2008) Identifying autoantigens as theranostic targets: antigen arrays and immunoproteomics approaches. Curr Opin Mol Ther 10(2), 107–115.

    CAS  PubMed  Google Scholar 

  49. Santra, S., Kaittanis, C., Grimm, J., and Perez, J. M. (2009) Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging. Small 5(16), 1862–1868.

    Article  CAS  PubMed  Google Scholar 

  50. Bruchez, M., Jr., Moronne, M., Gin, P., Weiss, S., and Alivisatos, A. P. (1998) Semiconductor nanocrystals as fluorescent biological labels. Science 281(5385), 2013–2016.

    Article  CAS  PubMed  Google Scholar 

  51. Chan, W. C., Maxwell, D. J., Gao, X., Bailey, R. E., Han, M., and Nie, S. (2002) Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol 13(1), 40–46.

    Article  CAS  PubMed  Google Scholar 

  52. O’Neal, D. P., Hirsch, L. R., Halas, N. J., Payne, J. D., West, J. L. (2004) Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett 209, 171–176.

    Google Scholar 

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Acknowledgments

This work was supported by a James and Esther King Biomedical Research Award (06NIR-05-8356), State of Florida-Department of Health and the University of Florida, Patricia Adams Cancer Nanotechnology Research Fund; the DiMarco American Cancer Society IRG.

Author information

Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, University of Florida, Gainesville, Florida, USA

    Stephen R. Grobmyer & Nobutaka Iwakuma

  2. Department of Materials Science and Engineering, Particle Engineering Research Center, University of Florida, Gainesville, Florida, USA

    Parvesh Sharma & Brij M. Moudgil

  3. St. Stephen’s College, Delhi University, Delhi, India

    Parvesh Sharma

Authors
  1. Stephen R. Grobmyer
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  2. Nobutaka Iwakuma
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  3. Parvesh Sharma
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  4. Brij M. Moudgil
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Editors and Affiliations

  1. Dept. Surgery, University of Florida, Gainesville, USA

    Stephen R. Grobmyer

  2. ERC - Engineering Research Center, University of Florida, Gainesville, USA

    Brij M. Moudgil

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Grobmyer, S.R., Iwakuma, N., Sharma, P., Moudgil, B.M. (2010). What Is Cancer Nanotechnology?. In: Grobmyer, S., Moudgil, B. (eds) Cancer Nanotechnology. Methods in Molecular Biology, vol 624. Humana Press. https://doi.org/10.1007/978-1-60761-609-2_1

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  • DOI: https://doi.org/10.1007/978-1-60761-609-2_1

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