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Diet in Vitamin A Research

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Retinoids

Part of the book series: Methods in Molecular Biology ((MIMB,volume 652))

Abstract

A properly formulated diet is an essential underpinning for all in vivo research. This chapter focuses on the use of diet in retinoid research from two perspectives: human research, in which diet is usually variable and analysis of dietary intake is paramount to interpreting the study’s results, and animal (rodent) research, in which diet is imposed as a factor in the experimental design, and the diet consumed is usually monotonous. Many standard rodent diets are nonpurified and the amount of vitamin A in the diet is unknown. Moreover, it is likely to be much higher than expected from the label. By using a well-formulated purified diet with an exact amount of vitamin A, retinoid status in rodents can be closely controlled to create specific physiological conditions that represent the wide range of vitamin A status present in human populations.

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Abbreviations

AIN:

American Institute of Nutrition

IOM:

Institute of Medicine

NRC:

National Research Council

RA:

retinoic acid

RDA:

recommended dietary allowance.

References

  1. Institute of Medicine. (2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, National Academy Press, Washington.

    Google Scholar 

  2. Haskell, M.J., Mazumder, R.N., Peerson, J.M., Jones, A.D., Wahed, M.A., Mahalanabis, D., Brown, K.H. (1999) Use of the deuterated-retinol-dilution technique to assess total-body vitamin A stores of adult volunteers consuming different amounts of vitamin A. Am. J. Clin. Nutr. 70, 874–780.

    Google Scholar 

  3. Tang, G.W., Qin, J., Dolnikowski, G.G., Russell, R.M. (2003) Short-term (intestinal) and long-term (postintestinal) conversion of beta-carotene to retinol in adults as assessed by a stable-isotope reference method. Am. J. Clin. Nutr. 78, 259–266.

    PubMed  CAS  Google Scholar 

  4. Ahmad, S.M., Haskell, M.J., Raqib, R., Stephensen, C.B. (2008) Men with low vitamin A stores respond adequately to primary yellow fever and secondary tetanus toxoid vaccination. J. Nutr. 138, 2276–2283.

    Article  PubMed  CAS  Google Scholar 

  5. Hargreaves, M.K., Baquet, C., Gamshadzahi, A. (1989) Diet, nutritional status, and cancer risk in American blacks. Nutr. Cancer 12, 1–28.

    Article  PubMed  CAS  Google Scholar 

  6. Fontham, E.T.H., Pickle, L.W., Haenszel, W., Correa, P., Lin, Y., Falk, R.T. (1988) Dietary vitamins A and C and lung cancer risk in Louisiana. Cancer 62, 2267–2273.

    Article  PubMed  CAS  Google Scholar 

  7. Paganini-Hill, A., Chao, A., Ross, R.K., Henderson, B.E. (1987) Vitamin A, β-carotene, and the risk of cancer: A prospective study. JNCI. 79, 443–448.

    PubMed  CAS  Google Scholar 

  8. Ross, A.C. (1994) Vitamin A and cancer. In: Carroll, K.K., Kritchevsky, D. (eds.), Nutrition and Disease Update, Cancer, AOCS Press, Champaign, IL, pp. 27–109.

    Google Scholar 

  9. National Cancer Institute. (2009) Short Dietary Assessment Methods. http://riskfactor.cancer.gov/diet/ and http://riskfactor.cancer.gov/diet/screeners/ (last accessed April 22, 2010).

  10. Smiciklas-Wright, H., Mitchell, D.C., Ledikwe, J.H. (2007) Dietary intake assessment: Methods for adults. In: Berdanier, C.D., Dwyer,J.T., Feldman, E.B. (eds.), Handbook of Nutrition and Food, 2nd ed, CRC Press, Boca Raton, FL, pp. 493–508.

    Google Scholar 

  11. Reeves, R.S., Pace, P.W. (2007) Use of food frequency questionnaires in minority populations. In: Berdanier, C.D., Dwyer, J.T., Feldman, E.B. (eds.), Handbook of Nutrition and Food, CRC Press, Boca Raton, FL, pp. 509–528.

    Google Scholar 

  12. Haskell, M.J., Lembcke, J.L., Salazar, M., Green, M.H., Peerson, J.M., Brown, K.H. (2003) Population-based plasma kinetics of an oral dose of [2H4]retinyl acetate among preschool-aged, Peruvian children. Am. J. Clin. Nutr. 77, 681–686.

    PubMed  CAS  Google Scholar 

  13. Murphy, S.P., White, K.K., Park, S.-Y., Sharma, S. (2007) Multivitamin-multimineral supplements’ effect on total nutrient intake. Am. J. Clin. Nutr. 85(suppl), 280S–284S.

    PubMed  CAS  Google Scholar 

  14. Briefel, R., Hanson, C., Fox, M.K., Novak, T., Ziegler, P. (2006) Feeding infants and toddlers study: Do vitamin and mineral supplements contribute to nutrient adequacy or excess among US infants and toddlers? J. Am. Diet. Assoc. 106, S52–S65.

    PubMed  CAS  Google Scholar 

  15. Mithen, R. (2007) Effect of genotype on micronutrient absorption and metabolism: A review of iron, copper, iodine and selenium, and folates. Int. J. Vitam. Nutr. Res. 77, 205–216.

    Article  PubMed  CAS  Google Scholar 

  16. Powers, H.J. (2005) Interaction among folate, riboflavin, genotype, and cancer, with reference to colorectal and cervical cancer. J Nutr. 135(Suppl), 2960S–2966S.

    PubMed  CAS  Google Scholar 

  17. Friso, S., Choi, S.W. (2005) Gene-nutrient interactions in one-carbon metabolism. Curr. Drug Metab. 6, 37–46.

    Article  PubMed  CAS  Google Scholar 

  18. Newberne, P.M., Fox, J.G. (1980) Nutritional adequacy and quality control of rodent diets. Lab. Anim. Sci. 30, 352–365.

    PubMed  CAS  Google Scholar 

  19. Feed Inspector's Manual. (2000) Chapter 4, Label Review, 2nd ed., Association of American Feed Control Officials Inspection and Sampling Committee. http://www.aafco.org/Portals/0/Public/COMPLETE_INSPECTORS_MANUAL.pdf (last accessed April 22, 2010).

  20. Tobin, G., Stevens, K.A., Russell, R.M. (2007) Nutrition. In: Fox, J.G., Barthold, S.W., Davisson, M.T., Newcomer, C.E., Quimby, F.W., Smith, A.L. (eds.), The Mouse in Biomedical Research, Academic, New York, pp. 321–384.

    Chapter  Google Scholar 

  21. Lipman, N.S. (2007) Design and analysis of research facilities for mice. In: Fox, J.G., Barthold, S.W., Davisson, M.T., Newcomer, C.E., Quimby, F.W., Smith, A.L. (eds.), The Mouse in Biomedical Research, 2nd ed. Academic, New York.

    Google Scholar 

  22. American Institute of Nutrition. (1977) Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J. Nutr. 107, 1340–1348.

    Google Scholar 

  23. American Institute of Nutrition. (1980) Second report of the ad hoc committee on standards for nutritional studies. J. Nutr. 110, 1726.

    Google Scholar 

  24. Wise, A. (ed.). (1991) Diet Formulation and Experimental Design for Laboratory Animal Studies, CRC Press, Boca Raton, FL.

    Google Scholar 

  25. Reeves, P.G. (1997) Components of the AIN-93 diets as improvements in the AIN-76A diet. J. Nutr. 127, 838S–841S.

    PubMed  CAS  Google Scholar 

  26. National Research Council. (1978) Nutrient Requirements of Laboratory Animals, 3rd ed. National Academies Press, Washington, DC.

    Google Scholar 

  27. National Research Council. (1995) Nutrient Requirements of Laboratory Animals, 4th ed. National Academies Press, Washington, DC.

    Google Scholar 

  28. Lieber, C.S., DeCarli, L.M. (1982) The feeding of alcohol in liquid diets: Two decades of applications and 1982 update. Alcohol Clin. Exp. Res . 6, 523–531.

    Article  PubMed  CAS  Google Scholar 

  29. Zolfaghari, R., Ross, A.C. (1995) Chronic vitamin A intake affects the expression of mRNA for apolipoprotein A-I, but not for nuclear retinoid receptors, in liver of young and aging Lewis rats. Arch. Biochem. Biophys. 323, 258–264.

    Article  PubMed  CAS  Google Scholar 

  30. Dawson, H.D., Li, N.Q., DeCicco, K.L., Nibert, J.A., Ross, A.C. (1999) Chronic marginal vitamin A status reduces natural killer cell number and function in aging Lewis rats. J. Nutr. 129, 1510–1517.

    PubMed  CAS  Google Scholar 

  31. Dawson, H.D., Yamamoto, J., Zolfaghari, R., Rosales, F., Dietz, J., Shimada, T., Li, N.-Q., Ross, A.C. (2000) Regulation of hepatic vitamin A storage in a rat model of controlled vitamin A status during aging. J. Nutr. 130, 1280–1286.

    PubMed  CAS  Google Scholar 

  32. Olson, J.A. (1984) Serum level of vitamin A and carotenoids as reflectors of nutritional status. J. Natl. Cancer Inst. 73, 1439–1444.

    PubMed  CAS  Google Scholar 

  33. Davila, M.E., Norris, L., Cleary, M.P., Ross, A.C. (1985) Vitamin A during lactation: Relationship of maternal diet to milk vitamin A content and to the vitamin A status of lactating rats and their pups. J. Nutr. 115, 1033–1041.

    PubMed  CAS  Google Scholar 

  34. Akohoue, S.A., Green, J.B., Green, M.H. (2006) Dietary vitamin A has both chronic and acute effects of vitamin A indices in lactating rats and their offspring. J. Nutr. 136, 128–132.

    PubMed  CAS  Google Scholar 

  35. Ross, A.C. (1986) Separation and quantitation of retinyl esters and retinol by high-performance liquid chromatography. Meth. Enzymol. 123, 68–74.

    Article  PubMed  CAS  Google Scholar 

  36. Smith, S.M., Levy, N.L., Hayes, C.E. (1987) Impaired immunity in vitamin A deficient mice. J. Nutr. 117, 857–865.

    PubMed  CAS  Google Scholar 

  37. Morriss-Kay, G.M., Sokolova, N. (1996) Embryonic development and pattern formation. FASEB J. 10, 961–968.

    PubMed  CAS  Google Scholar 

  38. Clagett-Dame, M., DeLuca, H.F. (2002) The role of vitamin A in mammalian reproduction and embryonic development. Annu. Rev. Nutr. 22, 347–381.

    Article  PubMed  CAS  Google Scholar 

  39. Clinton, S.K., Imrey, P.B., Alster, J.M., Simon, J., Truex, C.R., Visek, W.J. (1984) The combined effects of dietary protein and fat on 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats. J. Nutr. 114, 1213–1223.

    PubMed  CAS  Google Scholar 

  40. Donnelly, T.M., Brown, C.J. (2009) Rodent Husbandry and Care. http://www.veterinarypartner.com/Content.plx?P=A&A=2497&S=4 (last accessed April 22, 2010).

  41. National Organization of Bionutritionists. Well-Controlled Diet Studies in Humans: A Practical Guide to Design and Management. http://www.nabconnection.org/ (last accessed April 22, 2010).

  42. Berson, E.L. (2000) Nutrition and retinal degenerations. Int. Ophthalmol. Clin. 40, 93–111.

    Article  PubMed  CAS  Google Scholar 

  43. Coleman, H., Chew, E. (2007) Nutritional supplementation in age-related macular degeneration. Curr. Opin. Ophthalmol. 18, 220–223.

    Article  PubMed  Google Scholar 

  44. Keenan, K.P., Laroque, P., Dixit, R. (1998) Need for dietary control by caloric restriction in rodent toxicology and carcinogenicity studies. J. Toxicol. Environ. Health B Crit. Rev. 1, 135–148.

    Article  PubMed  CAS  Google Scholar 

  45. Cartaa, M., Stancampianoa, R., Troncib, E., Colluc, M., Usiellod, A., Morellib, M., Faddaa, F. (2006) Vitamin A deficiency induces motor impairments and striatal cholinergic dysfunction in rats. Neuroscience 139, 1163–1172.

    Article  Google Scholar 

  46. Brown, C.J., Donnelly, T.M. (2004) Rodent husbandry and care. Vet. Clin. North Am. Exot. Anim. Prac. 7, 201–225.

    Article  Google Scholar 

  47. World Health Organization. (1966) WHO Expert Committee on Biological Standardization Eighteenth Report. Technical report series, No. 329, Geneva.

    Google Scholar 

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Acknowledgments

Support: NIH grants CA-90214; DK-41479.

Author information

Authors and Affiliations

  1. Department of Nutritional Sciences and Huck Institute for the Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA

    A. Catharine Ross

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  1. A. Catharine Ross
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Editors and Affiliations

  1. David Geffen School of Medicine, Dept. Physiology, University of California, Los Angeles, Charles Young Dr. S. 650, Los Angeles, 90095-1751, California, USA

    Hui Sun

  2. , Jules Stein Eye Institute, UCLA School of Medicine, 100 Stein Plaza, BH-667, Los Angeles, 90095, California, USA

    Gabriel H. Travis

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Ross, A.C. (2010). Diet in Vitamin A Research. In: Sun, H., Travis, G. (eds) Retinoids. Methods in Molecular Biology, vol 652. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-325-1_17

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  • DOI: https://doi.org/10.1007/978-1-60327-325-1_17

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-324-4

  • Online ISBN: 978-1-60327-325-1

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