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Animal Models of Acute Surgical Pain

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Analgesia

Part of the book series: Methods in Molecular Biology ((MIMB,volume 617))

Abstract

Animal models of tissue injury have been used to investigate the mechanisms of pain. Here, we describe a variety of animal models that have been used to mimic acute surgical pain in human subjects, which include the plantar, tail, and gastrocnemius incision models. We also provide discussion on animal models of laparotomy, thoracotomy, visceral pain, and bone injury. Preclinical studies using these models have provided insights into the mechanisms and causes of acute surgical pain as well as the treatment options to control postsurgical pain.

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Authors and Affiliations

  1. Department of Anesthesia and Critical Care, Massachusetts General Hospital Center for Translational Pain Research, Harvard Medical School, Boston, MA, USA

    Hyangin Kim, Backil Sung & Jianren Mao

Authors
  1. Hyangin Kim
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  2. Backil Sung
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  3. Jianren Mao
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Corresponding author

Correspondence to Jianren Mao .

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Editors and Affiliations

  1. Dept. Pathology, Monmouth Medical Center, Second Ave. 300, Long Branch, 07750, USA

    Arpad Szallasi

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Kim, H., Sung, B., Mao, J. (2010). Animal Models of Acute Surgical Pain. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_3

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  • DOI: https://doi.org/10.1007/978-1-60327-323-7_3

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60327-322-0

  • Online ISBN: 978-1-60327-323-7

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