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RNA and DNA Microarrays

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Biological Microarrays

Part of the book series: Methods in Molecular Biology ((MIMB,volume 671))

Abstract

The development of microarray technology has revolutionized RNA and deoxyribonucleic acid (DNA) research. In contrast with traditional biological assays, microarrays allow the simultaneous measurement of tens of thousands of messenger RNA (mRNA) transcripts for gene expression or of genomic DNA fragments for copy number variation analysis. Over the past decade, genome-wide RNA or DNA microarray analysis has become an essential component of biology and biomedical research. The successful use of microarrays requires attention to unique issues of experimental design and execution. This chapter provides an overview of the methodology and applications of RNA and DNA microarrays in various areas of biological research.

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Acknowledgments

Our microarray research is supported by grants from NIH NIDDK and by a research contract from NIAID.

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Authors and Affiliations

  1. Neurology, Mount Sinai School of Medicine, New York, NY, USA

    Stuart C. Sealfon

  2. Departments of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY, USA

    Tearina T. Chu

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  1. Stuart C. Sealfon
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  2. Tearina T. Chu
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Correspondence to Stuart C. Sealfon .

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Editors and Affiliations

  1. , MIT Division of Health Sciences and Tech, Harvard Medical School, Landsdowne St. 65, Cambridge, 02139, Massachusetts, USA

    Ali Khademhosseini

  2. , Department of Mechanical and Aerospace E, Seoul National University, Kwanak-gu, Shinlim-dong 56-1-1, Seoul, 151-742, Korea, Republic of (South Korea)

    Kahp-Yang Suh

  3. Biophage Pharma, Inc., Royalmount Ave. 6100, Montreal, H4P 2R2, Québec, Canada

    Mohammed Zourob

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Sealfon, S.C., Chu, T.T. (2011). RNA and DNA Microarrays. In: Khademhosseini, A., Suh, KY., Zourob, M. (eds) Biological Microarrays. Methods in Molecular Biology, vol 671. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-551-0_1

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  • DOI: https://doi.org/10.1007/978-1-59745-551-0_1

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-934115-95-4

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