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Avoiding False Discoveries in Association Studies

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Linkage Disequilibrium and Association Mapping

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 376))

Abstract

We consider the problem of controlling false discoveries in association studies. We assume that the design of the study is adequate so that the “false discoveries” are potentially only because of random chance, not to confounding or other flaws. Under this premise, we review the statistical framework for hypothesis testing and correction for multiple comparisons. We consider in detail the currently accepted strategies in linkage analysis. We then examine the underlying similarities and differences between linkage and association studies and document some of the most recent methodological developments for association mapping.

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Author information

Authors and Affiliations

  1. Department of Human Genetics, UCLA School of Medicine, Los Angeles, CA

    Chiara Sabatti

Authors
  1. Chiara Sabatti
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Editor information

Editors and Affiliations

  1. Genetic Epidemiology and Bioinformatics Group, Human Genetics Division Southampton General Hospital, Southampton, UK

    Andrew R. Collins

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© 2007 Humana Press Inc.

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Sabatti, C. (2007). Avoiding False Discoveries in Association Studies. In: Collins, A.R. (eds) Linkage Disequilibrium and Association Mapping. Methods in Molecular Biology™, vol 376. Humana Press. https://doi.org/10.1007/978-1-59745-389-9_14

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  • DOI: https://doi.org/10.1007/978-1-59745-389-9_14

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-669-6

  • Online ISBN: 978-1-59745-389-9

  • eBook Packages: Springer Protocols

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