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Correlation of Caspase Activity and In Vitro Chemo-Response in Epithelial Ovarian Cancer Cell Lines

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Apoptosis and Cancer

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 414))

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Summary

The immediate assessment of response to therapy is most beneficial to ovarian cancer patients. This study shows the correlation of drug-induced caspase activation determined by western blot analysis and by Caspase-Glo™ assay. Our findings demonstrate that the use of the Caspase-Glo™ assay allows a simple, fast, and sensitive alternative for the evaluation of in vitro response to chemotherapy.

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References

  1. Schwartz, P.E. Current diagnosis and treatment modalities for ovarian cancer. Cancer Treat Res 107, 99–118 (2002).

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© 2008 Humana Press Inc.

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Alvero, A.B., Montagna, M.K., Mor, G. (2008). Correlation of Caspase Activity and In Vitro Chemo-Response in Epithelial Ovarian Cancer Cell Lines. In: Mor, G., Alvero, A.B. (eds) Apoptosis and Cancer. Methods in Molecular Biology™, vol 414. Humana Press. https://doi.org/10.1007/978-1-59745-339-4_7

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  • DOI: https://doi.org/10.1007/978-1-59745-339-4_7

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-457-9

  • Online ISBN: 978-1-59745-339-4

  • eBook Packages: Springer Protocols

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