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Modulation of Apoptosis to Reverse Chemoresistance

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Apoptosis and Cancer

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 414))

Summary

Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation. Modulation of the apoptotic cascade has been proposed as a new approach for the treatment of cancer. In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and potential use as chemosensitizer for chemoresistant ovarian cancer cells.

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Authors
  1. Gil Mor
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  2. Michele K. Montagna
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  3. Ayesha B. Alvero
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Editor information

Editors and Affiliations

  1. Department of Obstetrics Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT

    Gil Mor  & Ayesha B. Alvero  & 

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© 2008 Humana Press Inc.

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Mor, G., Montagna, M.K., Alvero, A.B. (2008). Modulation of Apoptosis to Reverse Chemoresistance. In: Mor, G., Alvero, A.B. (eds) Apoptosis and Cancer. Methods in Molecular Biology™, vol 414. Humana Press. https://doi.org/10.1007/978-1-59745-339-4_1

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  • DOI: https://doi.org/10.1007/978-1-59745-339-4_1

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-457-9

  • Online ISBN: 978-1-59745-339-4

  • eBook Packages: Springer Protocols

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