Abstract
Different animal models have been introduced recently to study the process of reparative dentinogenesis in response to injury-induced pulp exposure. Using a mouse model is advantageous over other animal models since mice can be genetically manipulated to examine specific cellular pathways and lineage trace the progeny of a single cell. However, enabling a standardized molar damage in mice is demanding due to the small size of the teeth compared to the available dental instruments. Here we describe a reproducible and reliable in vivo model that allows us to study dentinogenesis in the first maxillary mouse molar.
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Acknowledgments
Research was supported by the Swiss National Science Foundation.
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Babb, R.C., Chandrasekaran, D., Zaugg, L.K., Sharpe, P.T. (2019). A Mouse Model to Study Reparative Dentinogenesis. In: Papagerakis, P. (eds) Odontogenesis. Methods in Molecular Biology, vol 1922. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-9012-2_11
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DOI: https://doi.org/10.1007/978-1-4939-9012-2_11
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