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Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis

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Histamine Receptors as Drug Targets

Part of the book series: Methods in Pharmacology and Toxicology ((MIPT))

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Abstract

Atopic dermatitis is a common allergic skin disease characterized by eczematous lesions and pruritus. Experimental animal models are essential tools to study the underlying pathogenic mechanisms of atopic dermatitis. This chapter describes a mouse model with spontaneous manifestation of atopic dermatitis-like skin lesions (NC/Nga mice) and a protein-induced mouse model of atopic dermatitis (ovalbumin model) and discusses the role of the histamine receptor (HR) H1R and H4R antagonists in these models.

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Authors and Affiliations

  1. Institute for Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Bünteweg 17, 30559, Hannover, Germany

    Kristine Roßbach, Hanna Köchling, Jenny Wilzopolski & Manfred Kietzmann

  2. Department of Molecular Biomedical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC, USA

    Tomoki Fukuyama & Wolfgang Bäumer

Authors
  1. Kristine Roßbach
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  2. Hanna Köchling
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  3. Tomoki Fukuyama
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  4. Jenny Wilzopolski
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  5. Manfred Kietzmann
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  6. Wolfgang Bäumer
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Corresponding author

Correspondence to Kristine Roßbach .

Editor information

Editors and Affiliations

  1. Department of Pharmacology Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Ekaterini Tiligada

  2. Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, Belfast, Northern Ireland, United Kingdom

    Madeleine Ennis

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Roßbach, K., Köchling, H., Fukuyama, T., Wilzopolski, J., Kietzmann, M., Bäumer, W. (2017). Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis. In: Tiligada, E., Ennis, M. (eds) Histamine Receptors as Drug Targets. Methods in Pharmacology and Toxicology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6843-5_9

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  • DOI: https://doi.org/10.1007/978-1-4939-6843-5_9

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6841-1

  • Online ISBN: 978-1-4939-6843-5

  • eBook Packages: Springer Protocols

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